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二氢吡啶类钙通道阻滞剂控制血压的临床评价 被引量：8

Evaluation of Dihydropyridine Calcium Antagonists for Controlling Blood Pressure
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摘要 目的 :阐述二氢吡啶类钙通道阻滞剂的进展和临床应用的历程 ,评价其疗效与安全性。方法 :查阅近期国内外相关文献进行评价与分析。结果与结论 :二氢吡啶类钙通道阻滞剂近年来进展迅猛 ,已成为治疗心血管疾病的基本药物之一 ,尤其在对抗高血压上效果突出 ,已被多项应用循证医学方法的临床研究所证实。 OBJECTIVE:To summarize the aspect of clinical usage and progress on the dihydropyridine calcium antagonists,and evaluate its clinical efficacy and safety.METHODS:To collect medical literatures in recent years at home and abroad for reviewing.RESULTS & CONCLUSION:Advance in dihydropyridine calcium antagonists has been swiftly in recent years,it has already become one of the basic drugs for the treatment of cardiovascular disease, especially for the use of antihypertension.The results have been confirmed by clinical research of multiple evidence-based medicine.
作者 张石革 陈瑞红 梁建华
机构地区 北京大学北京积水潭医院
出处 《中国医院用药评价与分析》 2004年第4期202-206,共5页 Evaluation and Analysis of Drug-use in Hospitals of China
关键词 二氢吡啶类 钙通道阻滞剂 血压控制 心血管疾病 高血压 calcium channel blocker(CCB) dihydropyridine progress hypertension evidence-based medicine clinical evaluation
分类号 R544.1 [医药卫生—心血管疾病] R972.4 [医药卫生—药品]
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参考文献20

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二级参考文献14

  • 1戴玉华 余国膺.1995年关于钙拮抗剂的一场争论[J].医学进展,1996,1(2):3-3.
  • 2[1]Minami J, Kawano Y, Makino Y, et al. Effects of cilnidipine a novel dihydropyridine calcium antagonist, on autonomic function,ambulatory blood pressure and heart rate in patients with essential hypertension[J]. Br J Clin Pharmacol, 2000;50:615-620.
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  • 4[3]Rose GW, kanno Y, Ikebukuro H, et al. Cilnidipine is as effective as benazepril for control blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis[J]. Hypertens Res,2001;24:377-383.
  • 5[4]Onose Y,Oki T,Yamada H, et al. Effect of cilnidipine on left ventricular diastolic function in hypertensive patients as assessed by pulsed Doppler echocardiography and pulsed tissue Doppler imaging[J]. Jpn Cir J, 2001; 65:305-309.
  • 6[5]Ahaneku JE, Sakata K,Urano T, et al. Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during treatment of hypertension with cilnidipine[J]. Pharmacol Res, 2000; 41:81-84.
  • 7Circo A. Active dose finding for lercanidipine in a double-blind, placebo-contrilled design in patients with mild to moderate hypertension. J Cardiovasc Pharm, 1997, 29[ Suppl 2] :S21-S25.
  • 8Omboni S, Zanchetti A. Antihypertensive effecacy of lercanidipine at 2. 5 mg, 5 mg, and 10 mg in mild to moderate essential hypertensives assessed by clinic and ambulatory blood pressure measurements. J Hyperens, 1998, 16: 1831-1838.
  • 9Macchiarulo C, Pieri R, Mitolo DC, et al. Antihypertensive effects of six calcium antagonists: evidence from fourier analysis of 24-hour ambulatory blood pressure recordings. Curr Ther Res Clin Exp, 2001,62 : 236-263.
  • 10Hansson L, Zanchetti A, Carruthers G, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the hypertension optimal treatment (HOT) randomised trial.Lancet, 1998, 351:1755-1762.

共引文献120

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引证文献8

二级引证文献20

中国医院用药评价与分析
2004年 第4期

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