低分子肝素钠治疗不稳定型心绞痛临床剂量的探索

The Study of Low Molecular Weight Heparin for Unstable Angina Pectoris

目的 观察低分子肝素钠 (海普宁 )治疗不稳定型心绞痛 (UAP)的临床剂量。方法 将 58例UAP患者随机分为对照组 2 8例和低分子肝素组 (治疗组 ) 30例 ,治疗一周后比较两组疗效。结果 治疗组有效率 93 .3 % ,明显高于对照组的 67.8% (P <0 .0 5)。结论 在常规治疗基础上加用小剂量低分子肝素 0 .4ml,疗程一周治疗不稳定型心绞痛疗效可靠 ,副作用较少 ,能减少心肌梗死的发生。

Objective To investigate the dose of low molecular weight heparin (LMWH) for unstable angina pectoris (UAP). Methods 58 patients with unstable angina pectoris were divided into two groups randomly. 28 patients in control group received the conventional treatment, 30 patients in treatment group received the conventional treatment and low molecular weight heparin. Results The effective rate in a week was 93.3% in the treatment group, however it was 67.8% in the control group. The difference between two groups was significant (P<0.05). Conclusions The conventional treatment in combination with low dose LMWH is an effective and safe treatment for UAP with little side effect and it can reduce the incidence of acute myocardial infarction.