泮托拉唑预防重症脑出血并发应激性溃疡出血

Effect of Pantoprezole in Preventing Stress Ulcer Hemorrhage After Severe Cerebral Hemorrhage

目的 观察泮托拉唑治疗重症脑出血并发应激性溃疡出血的疗效。方法 随机将 68例患者分为泮托拉唑组 (38例 )和法莫替丁组 (30例 )进行对比观察。结果 2组应激性溃疡出血的发生率分别为 2 .6 %和 2 3 .3 % ,脑出血病死率为 1 3 .2 %和 36 .7% ,泮托拉唑组显著低于对照组 (P <0 .0 5)。结论 泮托拉唑预防重症脑出血并发应激性溃疡出血疗效确切 ,且无明显不良反应。

Objective To observe the efficacy of pantoprazole in preventing stress ulcer hemorrhage after severe cerebral hemorrhage. Methods 68 patients were divided into two groups randomly: pantoprezole group (38 cases) and famotidine group (30 cases). Results The morbidity of stress ulcer hemorrhage was 2.6% in pantoprezole group and 23.3% in famotidin group, the mortality of cerebral hemorrhage was 13.2% in pantoprezole group and 36.7% in famotidine group. Morbidity and morbidity were significantly lower in pantoprezole group than in famotidine group (P<0.05). Conclusions Pantoprezole is effective in preventing stress ulcer hemorrhage after severe cerebral hemorrhage.