2[2]Allan EH,Hilton DJ, Brown MA, et al . Osteoblasts display receptors for and responses to leukemia - inhibitory factor. J Cell Physiol,1990,145:110 - 119.
3[3]Rodan SB,Wesolowski G,Hilton DJ, et al. Leukemia inhibitory factor binds with high affinity to preosteoblastic RCT - 1 cells and potentiates the retinoic acid induction of alkaline phosphatase. Endocrinology, 1990,127:1602 - 1608.
4[4]Bellido T, Stahl N, Farruggella TJ, et al. Detection of receptors for interleukin - 6, interleukin - 11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells . J Clin Invest ,1996 , 97:431 -437.
5[5]Bellido T, Borba VZ ,Roberson P , et al. Activation of the Janus kinase/STAT ( signal transducer and activator of transcription) signal transduction pathway by interleukin - 6 - type cytokines promotes osteoblast differentiation. Endocrinology,1997,138:3666 -3676.
6[6]Abe E, Tanaka H, Ishimi Y, et al. Differentiation - inducing factor purified from conditioned medium of mitogen - treated spleen cell cultures stimulates bone resorption. Proc Natl Acad Sci USA, 1986,83:5958 - 5962.
7[7]Reid IR,Lowe C, Cornish J,et al . Leukemia inhibitory factor: a novel bone - active cytokine. Endocrinology, 1990,126:1416 - 1420.
8[8]Cornish J, Callon K, King A, et al . The effect of leukemia inhibitory factor on bone in vivo . Endocrinology, 1993,132:1359 - 1366.
9[9]Soueidan A, Gan OI, Gouin F, et al . Culturing of cells from giant cell tumour of bone on natural and synthetic calcified substrata: the effect of leukaemia inhibitory factor and vitamin D3 on the resorbing activity of osteoclast- like cells. Virchows Arch, 1995,426:469 -477.
10[10]Varghese S, Yu K, Canalis E . Leukemia inhibitory factor and oncostatin M stimulate collagenase -3 expression in osteoblasts. Am J Physiol, 1999,276: E465 - E471.
2Evans DB, Gerber B, Feyen JH. Recombinant human leukemia inhibitory factor is mitogenic for human bone-derived osteoblast-like cells[J]. Biochem Biophys Res Commun, 1994,199 (1) : 220 ~ 226.
3Lotz M, Moats T, Villiger DM, et al. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis[J]. J Clin Invest, 1992,90:888~896.
4Okarnoto H, Yamamura M,Morita Y, et al. The synovial expression and serum levels of-6, interleukin-11, leukemia inhibitory factor, and oneostain Min rheumatoid arthritis[J]. Arthritis-Rheum,1997,40(6) : 1096 ~ 1105.
6Alaaeddine N,Di Battista JA, Pelletier JP, et al. Differential effects of IL-8, LIF (Pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE (2) release and on signaling pathways in human OA synovial fibroblasts[ J ]. Cytokine, 1999,11(12) : 1020-1030.
7Henrotin YE, De Groote DD, Labasse AH, et al. Effects of exogenous IL-1 beta, TNF alpha, IL-6, IL-8 and LIF on cytokine production by uman articular chondrocytes[J]. Osteoarthritis Cartilage,1996,4(3) : 163~173.
3Lievre A,Milet J,Carayol J,et al.Genetic polymorphisms of MMP1,MMP3 and MMP7 gene promoter and risk ofcolorectal adenoma.BMC Cancer,2006,6:270.
4Sun T,Gao Y,Tan W,et al.Haplotypes in matrix metalloproteinase gene cluster on chromosome 11 q22 contribute to the risk of lung cancer development and progression.Clin Cancer Res,2006,12:7009-7017.
5Sauter W,Rosenberger A,Beckmann L,et al.Matrix metalloproteinase 1 (MMP1) is associated with earlyonset lung cancer.Cancer Epidemiol Biomarkers Prev,2008,17:1127-1135.
6Matthias VP,Laure T.A frequent functional SNP in the MMP 1 promoter is associated with higher disease severity in recessive dystrophic epidermolysis eullosa.humanmutation,2008,29:267-276.
7Leksrisakul P,Sangruchi S.A functional polymorphism in the matrix metalloproteinase-1 gene promoter is associated with susceptibility and aggressiveness of head and neck cancer.Int J Cancer,2006,118:2548-2553.
8Walch K,Nagele F,Zeillinger R,et al.A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women.Fertil Steril,2005,83:1565-1567.
9Zhu Y,Spitz MR,Lei L,et al.A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility.Cancer Res,2001,61:7825-7829.
10Yao JY,Wang Y,An J,et al.Mutation analysis of the Smad3 gene in human osteoarthritis.Eur J Hum Genet,2003,11:714-717.
