期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

凝血酶受体的生物学功能及在脑损伤中的双重作用 被引量：1

The biologic function of thrombase and it's double function in brain damage
下载PDF
导出
摘要 1978年,Carney和Cunningham首次鉴定凝血酶受体(thrombin receptor,TR).1991年,Vu TK等克隆了第一个TR.1994年,Coughlin等依据TR由蛋白酶水解机制激活,首次命名蛋白酶激活受体(protease-activated receptors,PAR)家族属于G蛋白偶联受体超家族.1994年,Nystedt等克隆了另一个由蛋白酶水解机制激活的受体,该受体以胰蛋白酶为底物,被命名为PAR-2,故最早得到克隆的TR也被称作PAR-1.此后Hiroaki等、Xu等分别报道了另两种TR,也都属于PAR家族,分别称为PAR-3和PAR-4.目前发现的PAR成员共有4个,分别为:PAR-1、PAR-2、PAR-3和PAR-4,其中PAR-1,PAR-3和PAR-4都是TR,而PAR-2为胰酶受体.由于"PAR"已被用于表示其他基因,故根据国际遗传学标准化命名委员会的建议,将人的PAR家族的基因依次命名为:PAR1g、PAR2g、PAR3g和PAR4g[1].凝血酶在凝血级联反应中发挥着关键作用,而且凝血酶有许多细胞外的效应,通过凝血酶影响的大多数细胞的功能是由PAR介导的[2].
作者 郑国庆 王小同
机构地区 温州医学院附属第二医院脑科中心
出处 《中国脑血管病杂志》 CAS 2004年第9期426-429,共4页 Chinese Journal of Cerebrovascular Diseases
关键词 凝血酶受体 生物学功能及 脑损伤 双重作用 脑耐受性
分类号 R651 [医药卫生—外科学]
  • 相关文献

参考文献22

  • 1[1]Kahn ML, Hammes SR, Botka C, et al. Gene and locus structure and chromosomal localization of the proteaseactivated receptor gene family. J Biol Chem, 1998 , 273:23290-23296.
  • 2[2]Coughlin SR. Thrombin signalling and protease-activatedreceptors. Nature, 2000,407: 258-264.
  • 3[3]Xi G, Reiser G, Keep RF. The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? J Neurochem, 2003, 84:3-9.
  • 4[4]Kaufmann R, Patt S, Zieger M, et al. The two-receptor system PAR- 1/PAR-4 mediates alpha-thrombin-induced Ca2 + (i) mobilization in human astrocytoma cells. J Cancer Res Clin Oncol, 2000 , 126: 91-94.
  • 5[5]Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. PAR3is a cofactor for PAR4 activation by thrombin. Nature,2000, 404: 609-613.
  • 6[6]Storck J, Vahland M, Breer T, et al. Brefeldin a inhibits thrombin receptor regeneration in human endothelial cells.Br J Haematol, 1997 , 99: 555-561.
  • 7[7]Hollenberg MD, Compton SJ. International union of pharmacology. XXⅧ. Proteinase-activated receptors. Pharmacol Rev, 2002 , 54: 203-217.
  • 8[8]Striggow F, Riek-Burchardt M, Kiesel A, et al. Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia. Eur J Neurosci, 2001, 14: 595-608.
  • 9[9]Wang H, Reiser G. Thrombin signaling in the brain: the role of protease-activated receptors. Biol Chem, 2003, 384:193- 202.
  • 10[10]Bartha K, Domotor E, Lanza F, et al. Identification of thrombin receptors in rat brain capillary endothelial cells. J Cereb Blood Flow Metab, 2000, 20: 175-182.

同被引文献8

  • 1Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats [ J ]. Stroke, 1989,20 ( 1 ) :84 - 91.
  • 2StoU G ,Jander S, Schroeter M. Inflammation and glial re- sponses in ischemic brain lesions [ J ]. Prog Neurobiol, 1998,56(2) :149 - 171.
  • 3Moiler T, Hanisch UK, Ransom BR. Thrombin-induced activation of cultured rodent microglia[ J ]. J Neurochem, 2000,75(4) :1 539 - 1 547.
  • 4Coughlin SR. Thmmbin signalling and protease-activated receptors[ J]. Nature ,2000,407 ( 6 801 ) :258 - 264.
  • 5Kaufmann R, Patt S, Zieger M, et al. The two-receptor system PAR-1/PAR-4 mediates alpha-thrombin-induced Ca^2 + (i) mobilization in human astrocytoma cells [ J ]. J Cancer Res Clin Oncol,2000,126 (2) : 91 - 94.
  • 6Masada T, Hua Y, Xi G, et al. Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist [ J ]. J Neurosurg,2001,95 (4) :680 - 686.
  • 7Rhauhman A, Anwar K, True A, et al. Thrombin-induced P65 homodimer binding to downsteam NF-KB site of the promotor mediates endothelial ICAM-1 expression and neutrophil adhesion[ J]. J Immol, 1999,162 (9) : 5 461 - 5 476.
  • 8吴家幂,杨倩,袁存国.亚低温对大鼠脑缺血再灌注后炎性反应的影响[J].中国神经免疫学和神经病学杂志,2003,10(2):116-118. 被引量：5

引证文献1

中国脑血管病杂志
2004年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部