摘要
目的:研究ras-p21蛋白在脑胶质细胞瘤中的表达。方法:用SP免疫组化方法检测79例脑胶质细胞瘤中r&s-p21蛋白的表达。结果:胶质瘤p21蛋白总阳性表达率为36.71%。其中星形细胞瘤、室管膜瘤及髓母细胞瘤中的表达率分别为44%、31.29%和15.38%,但三者之间统计学上无显著性差异(P>O.05)。Ⅰ、Ⅱ级肿瘤与Ⅲ、Ⅳ级肿瘤表达率之间统计学上也无显著性差异(P>0.05)。但高强度表达绝大多数见于Ⅲ、Ⅳ级肿瘤。结论:ras-p21蛋白的表达与胶质瘤的组织学类型及分化程度无关,但表达量能反映肿瘤的恶性程度。
To study the expression of ras-p21 protein in brain gliomas. Method: Using SP immunohistochemical method to determine the expression of ras-p21 protein in 79 brain gliomas. Result:Total positive rate of p21 protein in brain gliomas was 36. 7 %. The positive rates in astrocytoma, ependymoma and medulloblas-toma were 44%? 31. 29% and 15. 38% respectively, but there were no signifcant statastical difference (P >0.05). There was also not significant difference of the rates between grade Ⅰ , Ⅱ and grade Ⅲ , Ⅳ gliomas (P >0.05), but strong expression were seen in most cases of grade Ⅲ, Ⅳ tumors. Conclusion: The expression rates were not correlated with the cytological types and pathological grade of the gliomas, but the expression content of p21 protein was related to the malignancy of tumors.
出处
《中国微侵袭神经外科杂志》
CAS
1998年第4期265-267,共3页
Chinese Journal of Minimally Invasive Neurosurgery