复方甘草甜素联合苦参碱注射液治疗急性黄疸型病毒性肝炎临床观察

The Clinical Observation of the Compound Glycyrrihizin Injection plus Matrine in the Therapy of Acute Viral Hepatitis with Icterus

目的 观察复方甘草甜素联合苦参碱注射液治疗急性黄疽型病毒性肝炎临床疗效。方法 随机选择 80例急性黄疸型病毒性肝炎病人分成两组 ,观察组用复方甘草甜素注射液 10 0ml,苦参碱 2 0ml静脉滴注 ,均 1次 /d ,疗程视黄疸消退情况而定 ,对照组使用甘利欣 15 0mg ,苦黄注射液 40ml,1次 /d静脉滴注 ,主要观察ALT和STB的变化 ,同时观察症状、体征的变化。结果 观察组在治疗第 1,2周时ALT下降幅度明显较对照组大 ,第 3 ,4周则差异不显著 ;但观察组在治疗第 1,2 ,3 ,4周时STB下降幅度均较对照组大 ,差异显著 (P <0 0 5 )。结论 复方甘草甜素联合苦参碱注射液有明显降酶 ,退黄疗效 ,明显改善临床症状 。

Objective To observe the effect of compound glycyrrihizin injection plus matrine on acute viral hepatitis with icterus. Methods Eighty patients of acute viral hepatitis with icterus were selected and at random divided into two groups. Every one in the observing group was given with compound glycyrrihizin injection (100 ml) plus matrine injection (20 ml) via vein once a day. The therapeutic course was decided according to the condition of the icterus extinction. Each of the control group was administered with diammonium glycyrrhizinate capsules (150 mg) and with Kuhuang injection (40 ml, via vein) per day. What were observed mainly included the changes of ALT and STB, as well as the symptoms and physical sign.Results The descent of ALT was much more obvious in the observing group than in the control group in the first two weeks, which tended to unobvious descent in the second two weeks. The level of STB in the observing group decreased much more clearly than that in the control group in the first four weeks. Conclusion Compound glycyrrihizin injection plus matrine has obvious effect on decreasing icterus and aminopherase, and on improving the clinical symptoms without adverse reaction as well.