无名异冲剂促进去卵巢大鼠骨质疏松性骨折愈合的机制研究

Study on Mechanism of Pyrolusite Powder Preparation for Infusion to Improve Osteoporotic Fracture Healing in Desovarian Rats

为探讨无名异冲剂促进去卵巢 SD大鼠骨质疏松性骨折愈合的机制 ,用 48只 6月龄雄性 SD大鼠建立骨质疏松性骨折模型 ,随机分为模型组、跳骨片组、仙灵骨葆组、无名异冲剂组 ,于灌胃后 2周、4周取材 ,观察 X线片、骨密度、光镜 ,骨痂钙、磷、胶原含量 ,结果显示灌胃第 2周时 ,各组动物各项指标均无显著性差异 ;第4周时 ,无名异冲剂组的骨密度 ,骨痂钙、磷、胶原含量的检测结果与模型组有显著性差异 ( P<0 .0 5 ) ,X线及光镜观察骨痂的生长情况 ,无名异冲剂组也优于模型组 ,说明无名异冲剂能够通过提高骨密度 ,改善骨骼钙、磷、胶原的代谢 ,促进骨折端骨痂的生长 ,达到治疗骨质疏松性骨折的目的。

To discuss the mechanism of pyrolusite powder preparation for infusion to improve osteoporotic fracture healing in desovarian rats,Using 48 six-month-old female SD rats to make osteoporotic fracture models and dividing them into model group、Tiaogu tablets group、Xianlinggubao group and Pyrolusite powder preparation for infusion group at random.Then draw the material after 2 and 4 weeks of lavage respectively to observe X-ray picture,bone density,light microscope image and contents of calcium,phosphor,collogen in osteotylus.The results showed that there was no significant difference in all of the indexes among each group after 2 weeks of lavage,while during the 4\+\{th\} week,there were significant differences in bone density and contents of calcium,phosphor,collogen in osteotylus between pyrolusite group and model group(P<0.05),the growth condition of osteotylus in pyrolusite group observed by X-ray picture and light microscope is better than model group as well.It can be said that pyrolusite powder preparation for infusion can cure osteoporotic fracture by enhancing the bone density,improving the metabolism of bone calcium,phosphor and collogn as well as accelerating the growth of osteotylus in the fractured end.