P(NIPA-co-HEMA)与PNIPA/P(HEMA)IPN水凝胶的辐射聚合与可控缓释研究

Radiation polymerization and controlled drug release of P(NIPA-co-HEMA) and PNIPA/P(HEMA) IPN hydrogels

采用辐射聚合方法制备了聚N-异丙基丙烯酰胺(PNIPA)均聚物、N?异丙基丙烯酰胺(NIPA)与甲基丙烯酸2?羟基乙酯(HEMA)共聚物(P(NIPA?co?HEMA))和PNIPA/P(HEMA)互穿网络(InterpenetratingPolymerNetwork,IPN)水凝胶。研究了水凝胶溶胀度的温度依赖性;讨论了剂量率和吸收剂量对辐射聚合的影响,单体浓度及其配比和聚合介质对水凝胶的相转变温度、溶胀度和溶胀?消溶胀动力学的影响;并以木瓜蛋白酶作为模型药物,对水凝胶进行药物释放测定。实验结果表明,较为适宜的水凝胶在剂量率1kGy/h,吸收剂量30—40kGy,单体浓度10%和聚合介质正丁醇中辐射合成。此类共聚与互穿网络水凝胶适用于药物的可控释放。

Hydrogels of poly N?isopropylacrylamide (PNIPA), poly (N?isopropylacrylamide?co?2?hydroxyethyl methacrylate) (P(NIPA?co?HEMA)) and PNIPA/P(HEMA) IPN (Interpenetrating Polymer Network) were prepared by radiation polymerization. Dependence of their swelling behavior on temperature was studied. Effects of absorbed dose and dose rate on polymerization, feed monomer concentration and ratio, and polymerization medium on phase transition temperature, swelling ratio, and swelling and deswelling kinetics of these hydrogels were disscused. Papain (PAP) was provided a model drug. An investigation of controlled drug release of the hydrogels was conducted. Ac- cording to the experimental results, the hydrogels with optimum performances were produced at absorbed dose rate of 1kGy/h, total dose of 30—40kGy, 10% total monomer concentration, and in polymerization medium of n?butyl al- cohol. These copolymer and IPN hydrogels were promising materials for developing controlled drug release system.