胃增生性息肉危险因素分析

Risk factor of gastric hyperplastic polyps

目的研究胃增生性息肉与年龄、性别、幽门螺杆菌感染、慢性萎缩性胃炎等危险因素。方法12 454例次胃镜检查,发现胃息肉样病变182例,病理确诊为增生性息肉88例;对照组为经胃镜检查的连续患者496例。幽门螺杆菌检测采用快速尿素酶检查和组织学检查,其中之一阳性为幽门螺杆菌阳性。结果增生性息肉组女性65.91%(58/88),对照组51.61%(256/496),差异有显著性(P<0.05)。增生性息肉组>50岁70.45%(62/88),对照组52.62%(261/496),差异有显著性(P<0.01)。增生性息肉组幽门螺杆菌阳性59%(52/88),对照组46.98%(233/498),差异有显著性(P<0.05)。增生性息肉组肠上皮化生和/或萎缩性胃炎21.59%(19/88),对照组7.46%(37/459)差异有显著性(P<0.01)。结论女性、>50岁、幽门螺杆菌感染、肠上皮化生和/或萎缩性胃炎是胃增生性息肉的危险因素。

Objective: To detect risk factors of gastric hyperplastic polyps. Methods: 88 patients with hyperplastic polyps and 496 control were enrolled. Helicobacter pylori were detected by rapid urease test and histological examination of gastrical mucosal biopsies, helicobercter pylori status were considered positive if one or more these tests were positive. Biospies were taken in polyps and antrum for pathology examination. Results: Females with hyperplastic polyps were more frequently than control (65.91% vs 51.61%). Over 50 years old patients with hyperplastic polyps were more common than control. Positive rate of Helicobacter pylori in patients with hyperplastic polyps was significantly higher then that in control (59.09% vs 47.96%, P<0.05). Intestinal metaplasia and/or atrophy gastritis were more common in patients with hyperplastic polyps than in control (21.59% vs 7.46%, P<0.01). Conclusions: Female, > years old, helicobacter pylori infection and intestinal metaplasia and/or atrophy gastritis are risk factors of gastric hyperplastic polyps.