用微核试验来评价复方银耳制剂的抗辐射作用

Use of micronucleus test in evaluating radioprotective action of mixed tremella preparation

采用微核试验来评价一种抗辐射新药复方银耳制剂(下称银参饮)对受1Gyγ射线急性照射犬的辐射防护作用。实验分成银耳,胱胺,银参饮高、低剂量及照射对照五个组。结果显示,预防服用银参饮具有良好的抗辐射作用,其抗放效价类似于胱胺而明显高于银耳组。各组的剂量减低系数分别为:银参饮高剂量组2.01、银参饮低剂量组1.72、胱胺组1.55、银耳组1.11。

The radioprotective action of mixed tremella preparation(Yinshen Yin) on whole body gamma irradiated dogs has been studied. 25 male dogs were divided into five groups: tremella, mercaminum,Yinshen Yin at high dose, Yinshen Yin at low dose and control. All the dogs were given above drugs in 10 successive days before acute exposure of 1 Gy radiation. The results showed that the prophylaxtic use of Yinshen Yin had good anti- irradiation effect, and the radioprotective effect was similar to the mercaminum, but significantly higher than tremella. Thereby it was considered as a good radioprotective agent. The dose reduction factor in different groups were: Yinshen Yin high dose 2.01, Yinshen Yin low dose group 1.72, mercaminum group 1.55 and tremella group 1.11.