植物多糖的免疫调节及抗肿瘤活性研究

Research on the Immunomodulation and Anti-tumor Activity of Plant Polysaccharides

目前,对恶性肿瘤的治疗,除手术、放疗和化疗三大治疗手段外,以免疫治疗为代表的肿瘤生物治疗已成为重要的肿瘤辅助治疗方法.正常人的免疫系统能识别和杀死恶性肿瘤细胞,免疫防护能力差或对不正常细胞识别能力差,均能导致癌症的发生率增高.因此,免疫刺激剂和免疫调节剂被认为是潜在的抗癌剂.多糖类就是一种重要的生物反应调节剂.植物多糖可通过对荷瘤机体的免疫调节作用达到抗肿瘤的效果已得到世界的公认.针对多种植物类多糖的免疫调节作用及抗肿瘤活性作一综述.

Immunotherapy as a representation of biology therapy has become very important adjunant of cancer treatment except for operation, radiotherapy and chemotherapy. The normal immunity system can identify and kill tumor cells, however, the occurrence rate of tumor will enhance if it lacks of the ability of immunologic defence or immunological recognition. Therefore, immunostimulant and immunoregulator are regarded as potential antitumor agent. Polysaccharide is a kind of very important biological response modifier. It has been recognized all over the world and plant polysaccharides have anti-tumor effect through their immunomodulating effect on the organisms which carried tumor. The immunomodulating effect and anti-tumor activity of many kinds of plant polysaccharides are introduced in this article.