应变成像对肥厚型心肌病左室纵向局部心肌收缩功能的研究

Assessment of left ventricular longitudinal regional myocardial systolic function by strain imaging in patients with hypertrophic cardiomyopathy.

目的 评价肥厚型心肌病 (HCM)患者左心室纵向局部心肌收缩功能。方法 应变成像模式下 ,对 18例HCM患者和 17例正常人左心室各室壁不同水平心肌节段在长轴方向上的应变曲线进行分析 ,测量收缩期峰值应变。结果 HCM组各室壁节段收缩期峰值应变均显著低于正常对照组相应室壁节段 (P <0 .0 5 ) ;室间隔中段局部心肌收缩期峰值应变分别与室间隔厚度以及IVS/PW比值具有相关性 (r1=0 .76 2 ,r2 =0 .6 70 ,P <0 .0 1)。结论 HCM患者局部心肌收缩功能受损 ,且左室形态学异常与局部心肌功能的异常具有相关性 ;应变成像能够定性。

Objective This study was performed to assess the left ventricular longitudinal regional myocardial systolic function on apical views by strain imaging echocardiography in patients with hypertrophic cardiomyopathy(HCM).Methods In 18 patients with HCM and 17 healthy subjects, strain imaging echocardiography was performed on apical long-axis, two-chamber, and four-chamber views. For each wall, regional myocardial systolic strain was assessed at the basal, mid, and apical level respectively. And the peak systolic strain of each segment was measured and all the results were compared between both groups.Results Patients with HCM had reduced peak systolic strain at the every segment of different walls when compared with healthy subjects. In HCM, heterogeneities were seen among most of the myocardial segments at different level. There were significant correlations between the midseptal peak systolic strain and the thickness of IVS(r= 0.762), so was between the midseptal peak systolic strain and the IVS to LVPW thickness ratio (r= 0.670).Conclusion This study's results demonstrate that the left ventricular longitudinal regional myocardial systolic function is abnormal in HCM. Therefore, the degrees of left ventricle hypertrophy and asymmetry are related to the myocardial regional systolic function in HCM. Strain imaging has the potential to assess regional myocardial systolic function qualitatively and quantificationally.