摘要
1以青霉素 G 钾为原料,采用过氧乙酸作氧化剂合成青霉素 G 亚砜2加入 BSU 生成青霉素 G 亚砜硅酯,在HB_r4-甲基吡啶催化下扩环制备头泡 G酸。
1 Penici11in G potassium salt can be oxidized by Peraceticacid to give sul foxide 2 The 7-(phenylacetamido)deacetoxy- cephalosporin acid was prepared byring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N—dimethylsilylurca) using HBr—4—methylpyridine as catalyst.
出处
《黑龙江科技信息》
2004年第8期187-187,共1页
Heilongjiang Science and Technology Information
关键词
青霉素G钾
过氧乙酸
青霉素G亚砜
三甲基硅脲
头孢
G酸扩环
制备工艺
Penicillin G potassium salt
Peracetic acid
Penicillin G sulfoxide N,N—dimethylsilylurea
phenylacetamido—deacetoxycephalosporin
acid,silylation,catalyticring
expansion,preparation
