重型肝炎TGF-α、TNF-α、IL-1β改变的初步研究

Study on TGF-α,TNF-α and IL- 1β changes of severe hepatitis

研究重型肝炎病程中TGF-α、TNF-α、IL-1β的改变。23例进入研究,用放免法集中检测血清标本。急性期的三种细胞因子均显著高于正常对照(P<0.001)。恢复的TGF-α高于急性期(P=0.092)。TNF-α、IL-1β升高不明显(P=0.944,P=0.73s)。存活组14例,未存活组9例。急性期、恢复期或病情恶化时的三种细胞因子均显著高于正常对照(P<0.05)。存活组恢复期的TGF-α显著高于急性期(P=0.042),TNF-α、IL-1β比急性期升高,但差异不显著(P=0.948,P=0.992)。未存活组病情恶化时的TGF-α、IL-1β也明显高于急性期(P=0.050,P=0.062),TNF-α略升高(P=0.567)。两种炎症细胞因子在重型肝炎的发生、发展中起重要作用。TGF-α的血清浓度似乎影响病情转归。

To investigate the changes during the duration of TGF - α, TNF·· α and IL - 1β in patients with severe hepatitis. Double serums, which were preserved by low temperature - 80℃ were detected br radio - immunity assay. In acute stage, three kinds of cytokines of severe hepatitis were significantly higher (P < 0.001), TGF - α at recovery was significantly higher than in acute (P = 0.092),and TNF- a and EL- 1β were not so clear ( P = 0.944, P = 0 738). 14 patients were in survival and 9 in unsurvival group. The cytokines as mentioned above were significantly higher (P < 0.05). It was clear that the survivors at recovery TGF a was higher than at acute (P =0.042). There was no significant difference in TNF-αand IL- 1β( P = 0.948, P = 0.992) . TGF-αand IL- 1β of unsurvivors at exacerbation were significantly higher than at acute stage ( P = 0.50, P - 0.062) and TNF - αlittle bit higher ( P = 0.567). Two kinds of inflammatory cytokines took an important role in the occurrence and development of severe hepatitis. It seemed that TGF - αserum concentration affec ted prognosis of the disease.