原发性肝细胞癌中生存素的表达及与Bcl-xl的相关性研究

Expression of survivin and Bcl - xl gene in human primary HCC and their relationship study

探讨生存素(Survivin)基因在肝细胞癌中的表达与凋亡抑制基因bcl-xl的相关性。利用免疫组化(IHC)-Envision法检测了68例原发性肝细胞癌、癌旁肝组织和12例正常肝组织中survivin及Bcl-xl的表达。survivin的阳性表达与肝细胞癌的侵袭转移倾向密切相关(P<0.05),和HCC术后生存率显著相关(P<0.01),survivin的表达与bcl-xl阳性表达密切相关(P<0.05)。survivin的过表达,可作为判断肿瘤术后预后的指标。

To investigate the relationship between survivin and Bcl - xl gene expression in human hepatocellular carcinoma(HCC). Significant relationships were found between survivin positive expression an 1 metastasis in HCC ( P < 0.05) . Significant relationships were also found between survivin positive and Bel - xl gene expression ( P < 0.05) , and survival rate after operation ( P < 0.01).