糖尿病下肢大血管病变易患因素探讨

A STUDY OF RISK FACTORS FOR LEG VASCULAR DISRASE IN DIABETES

对糖尿病下肢大血管病变(早期)、闭塞性血管病变及其16种可能危险因素分别进行研究分析。结果表明,早期血管病变的易患因素依次为年龄、病程、BP、FPG、纤维蛋白原和TG;除纤维蛋白原外均与早期血管病变呈正相关。闭塞性血管病变易患因素依次为年龄、纤维蛋白原、FPG、女性性别、BP和VIIIR:Ag;均与闭塞性血管病变呈正相关。本文尚分析了下肢早期血管病变及闭塞性血管病变在发病环节上的可能联系和区别。积极控制有关易患因素,有助于防治下肢早期血管病变的发生发展。

76 diabetic patients (males 41, females 35) were analyzed. The diabetics were divided into3 subgroups according to the patients with or without leg vascular diseases by ultrasounddoppler. 16 potential risk factors of diabetic leg vascular disease (earlier vascular diseasegroup and occlusive arterial disease group) wereevaluated by multivariate stepwise regres-sion analysis. The results showed that age (P<0.01), diabetes duration (P<0.01), BP(P<0.01), FPG (P<0.05), fibrinogen (P<0.05 ) and TG (P>0.05) were found be riskfactors of the earlier ieg vascular disease in diabetes. Furthermore, these risk factorswere positively related to the development of earlier leg vascular disease except fibrino-gen. The risk factors of fhe occlusive arterial disease of lower extremities in diabetesincluded age (P<0.01), fibrinogen (P<0.01), FPG (P<0.01), female sex (P<0.01),BP (P<0.05) and VⅢR: Ag (P>0.05). Moreover, these risk factors were positivelycorrelated to the development of occlusive arterial disease. Besides, possible relationsand difference in pathogenesis between the earlier leg vascular disease and the occlusivearterial disease of lower extremities were discussed. Based on our results, to control therisk factors is helpful in the prevention of the development of leg vascular disease indiabetes.