视神经脊髓炎的T细胞亚型的分析

Analysis of T cells subsets in neuromyelitis optica

目的探讨末梢血T细胞亚型在视神经脊髓炎及其临床分期中的特点及变化。方法利用流式细胞仪测定并分析视神经脊髓炎和健康对照的末梢血中CD4+记忆T细胞的表面受体。结果与健康对照比较视神经脊髓炎及其复发期时的CD4+CD45RO+CD62L-细胞显著增加。结论在视神经脊髓炎是以I型辅助性T细胞反应占优势,在复发期这种反应的优势比缓解期要明显提高。同时也说明对T细胞亚型进行分析对神经系统自身免疫性疾病的诊断及治疗有一定的参考价值。

Objective Analysis of T cells subsets in neuromyelitis optica (NMO) during relapse and remission. Methods Examined surface receptors of memory CD4+ T cells by flow cytometry in peripheral blood from patients with NMO. Healthy subjects were also examined as controls. Results Patients with NMO during relapse phase showed a significantly higher percentage of CD4+CD45RO+ CD62L- T cells. Conclusion Type I help T cells (Th1) response was predominant in NMO, especially higher in the relapse phase of NMO than the healthy controls but not so high in remission phase of NMO. It was suggested a flow cytometry analysis of T cells subsets could be useful for diagnosis and treatment of the differentiating autoimmune disease of nervous system.