小儿多器官功能衰竭时急性胃肠功能障碍的发病因素探讨

Discussion about Episode Factors of Gastrointestinal Dysfunction in Children with MODS

目的 探讨小儿多器官功能衰竭 (MODS)时急性胃肠功能障碍的发病因素。方法 比较MODS患儿在合并感染、不同程度缺氧、酸中毒情况下胃肠功能障碍的发生率 ,观察其发生率与三者的线性依从关系。结果 原发病为感染性疾病的MODS患儿胃肠功能障碍的发生率为 4 0 2 0 % ,与非感染性疾病组 (2 1 2 1% )间差别有显著性意义 (χ2 =3 92 ,P <0 0 5 ) ;MODS患儿中处于缺氧状态者胃肠功能障碍的发生率为 38 83% ,非缺氧者的发生率为 18 75 % ,二者间差别有显著性意义 (χ2 =4 38,P <0 0 5 ) ,且胃肠功能障碍的发生率随着缺氧程度的加重有增加的趋势 (χ2 趋势 =13 4 5 ,P <0 0 1) ;MODS患儿中合并酸中毒者胃肠功能障碍的发生率为 4 0 6 6 % ,非酸中毒者为 18 4 2 % ,二者间差别有显著性意义 (χ2 =5 90 ,P <0 0 1) ,且胃肠功能障碍的发生率随着酸中毒程度的加重有增加的趋势 (χ2 趋势=8 4 4 ,P <0 0 1)。结论 胃肠功能障碍的发生与感染、缺氧程度、酸中毒程度有关。

Objective To investigate the episode factors of gastrointestinal dysfunction in children with MODS.Methods Comparing the frequency of gastrointestinal function failure in children with MODS infections, anoxia and oxidizes in order to observe the line relationship between the occurrence rate and the three situations.Results The frequency of gastrointestinal dysfunction in infection children was significantly higher than that of the non-infection (40.2% vs 21.21%,χ2=3.92,P<0.05). The frequency of gastrointestinal dysfunction of anoxia chidren was significantly higher than that of the normal (38.83% vs 18.75%,χ2=4.38,P<0.05), and the frequency of gastrointestinal dysfunction is related to the degree of anoxia (χ2 趋势=13.45,P<0.01). The frequency of gastrointestinal dysfunction of oxidisis children was significantly higher than that of the normal (40.66% vs 18.42%,χ2=5.90,P<0.01), and the frequency of gastrointestinal dysfunction increased to the degree of oxidisis (χ2 趋势=8.44,P<0.01).Conclusion The occurrence of gastrointestinal dysfunction is related to infections, the degree of anoxia and oxidizes.