组织学类型和临床分期对中心型非小细胞肺癌浸润近端支气管壁的影响

The Effects of Different Types and pTNM Stages on Proximal Bronchial Extension in Hilar Type Non-Small Cell Lung Cancer

目的 :探讨中心型非小细胞肺癌不同的病理组织学类型与 pTNM分期对癌细胞浸润近端支气管壁长度的影响 ,为术式的选择提供临床病理依据。方法 :86例原发性中心型非小细胞肺癌的手术标本 ,用细探针探测支气管腔 ,沿探针剖开支气管壁全层至肿瘤处 ,测量肿瘤边缘至支气管切缘的最近距离 ,对肿瘤至支气管切缘的管壁进行连续取材 ,常规病理制片、显微镜下观察组织学类型 ,测量癌细胞浸润近端支气管的长度。结果 :Ⅲa期腺癌最长 ,为 (1.91±0.36)cm ,Ⅰb期鳞癌最短为 (0.39±0.15)cm ,且差别有统计学意义。结论 :在原发性中心型非小细胞肺癌中 ,病理组织学类型、pTNM分期与癌细胞浸润近端支气管壁的长度有关 ,可作为选择术式的依据之一。

Objective:To investigate the effects of different types and pTNM stages on proximal bronchial extension in hilar type non_small cell lung cancer(NSCLC)and provide a clinicopathological basis for a curative resection.Methods:Eighty_six surgical specimens of primary hilar type NSCLC were collected.Macroscopic and microscopic proximal bronchial invasion lengths were measured from bronchial resection margins to tumor edges.Results:The invasive lengths of adenocarcinomas of stageⅢa were the longest(1.91±0.36)cm.The invasive lengths of squamous cell carcinomas of stageⅠb were the shortest(0.39±0.15)cm,which were sigˉnificantly different(P<0.05).Conclusion:The extension of invasion is correlated with the histopathologic type of cancer and TNM classification,which is one of the clinicopathological bases for a curative resection.