摘要
研究了30例乳腺癌的性类固醇激素受体含量和阳性检出率。乳癌组织胞液与^(3H)-睾酮,^(3H)-雌二醇和^(3H)-孕酮的最大特异结合量分别是154.2,121.6和159.0 fmol/mg胞液蛋白;它与三种标记配基的结合亲和力各为0.21,4.65和1.03nM。30例乳腺癌AR、ER和PR的阳性检出率分别是33.3%,70%和60%。不同病理类型乳腺癌间的AR、ER和PR阳性检出率差异有统计学意义。二元线性回归分析结果表明同时含有三种受体的乳腺癌AR的含量与ER和PR的含量无明显的相关关系。
Frequency and concentration of sexual steroid hormone receptors are described in 30patients with breast cancer. The specific bindings of H-Testosterone, H-Estrogen and ~3H-Progesterone in cytosol of breast cancer specimens contained 154.2, 121.6 and 159.0fmol/mgprotein, with binding affinities (Kd value) of 0.21, 4.65 and 1.03 nM respectively. Androgenreceptor, estrogen receptor and progestereon receptor were positive in 33.3%, 70%and 60% respectively. The pathological type of assayed tissue significantly affectedAndrogen receptor (AR), Estrogen receptor (ER) and Progesterone receptor (PR) positivity(P=0.013, 0.0007 and 0.0002 respectively). The result of multiple linear regressionanalysis indicated that there was no obvious relationship between content of AR and thatof ER and PR.
关键词
乳腺癌
雄激素受体
雌激素受体
androgen receptor
estrogen receptor
progesterone receptor
human breast cancer