红曲红色素组分Ⅰ对实验小鼠脂质代谢的影响

Effect of MRPI Extracted from Red Kojic on Lipid Metabolism in Mouse

目的:观察红曲红色素组分Ⅰ(Monascus red pigments section I,MRPI)对实验小鼠血脂代谢的影响。方法:昆明种雌性小鼠48只,按血脂水平分为6组:正常对照组、高脂对照组、绞股蓝总甙阳性对照组、MRPI低、中、高剂量组。正常对照组喂饲基础饲料,其它各组喂饲高脂饲料;按剂量分别灌胃给药6w,禁食12h后,测定小鼠血脂水平和相关指标。结果:实验6w末,MRPI低、中、高各剂量(10、50、100mg/kg·d)组使实验小鼠血清AI值(TC-HDL-C/HDL-C)均极显著低于高脂组(p<0.01);MRPI中、高各剂量组和绞股蓝总甙阳性对照组使实验小鼠血清TC、血清TG、血清LDL-C和肝组织TC均极显著低于高脂组(p<0.01);MRPI低、中、高剂量组血脂水平与高脂组相比,显著升高血清HDL-C。结论:提示MRPI红曲红色素组分I对实验小鼠血清血脂代谢具有良好的脂质代谢调节作用,有效抑制脂质过氧化和预防动脉粥样硬化作用,且呈剂量正相关关系。

Objective: To investigate the effect of MRPI(Monascus red pigments section I) extracted from Red Kojic on lipidmetabolism in mouse fed with high-fat diet. Methods: According to serum lipids level,48 female Kunming mouse were dividedinto 6 groups: (A)normal control group;(B)high-fat control group;(C)Gpenosides control group; (D) MRPI little dose group; (E)MRPI middle dose group; (F) MRPI high dose group. A group was fed basic diet and the other groups were fed high-fat diet forsix weeks. A and B groups were ig normal water, C groups was ig Gpenosides 20mg/kg·d,and D, E, F groups were ig MRPI10, 50 and 100mg/kg·d respectively .Blood lipid levels were determined after starved 12h. Results: (1) 6w later, serum TC,TG and LDL-C level significantly lower in C,D,E,F groups than in B group. Serum HDL-C level significantly higher in E groupsthan in B group; (2)serum AI level significantly lower in D,E,F groups than in B group.(3)hepatic TC and MDA level significantlylower in C,D,E,F groups than in B group. Conclusion: It suggested that MRPI(Monascus red pigments section I) would affecton lipid metabolism, and might suppress lipid peroxidation effectively and prevent atherosclerosis(AS).