结核性与非结核炎性和恶性胸腔积液中γ-干扰素水平的比较

Interferon-γ level in tuberculous and non-tuberculous inflammatory and malignant pleural effusions

目的 检测结核性、非结核炎性及恶性胸腔积液中γ 干扰素的水平 ,探讨结核性与非结核性及恶性胸腔积液的γ 干扰素水平在鉴别诊断中的意义。方法 采用双抗体夹心ELISA法 ,对 5 1例结核性胸膜炎患者、30例恶性胸膜炎患者、2 0例非结核炎性胸膜炎患者胸液中的γ 干扰素水平进行检测。结果 3组γ 干扰素水平 (x±s )结核性胸膜炎组为 5 5 3.33± 70 .89pg ml,恶性胸膜炎组为 5 4.6 4± 36 .37pg ml、非结核炎性胸膜炎组为 5 8.75± 4 7.2 6 pg ml。 3组比较结核性胸膜炎组明显高于其他组 (P <0 .0 1)。结论 γ 干扰素检测可以作为结核性胸膜炎诊断的重要参考指标。

Objective To detect interferon-γ level in tuberculous and non-tuberculous inflammatory and malignant pleural effusions,and explore its role for differentiation of diagnosis.Methods To detect interferon-γ level of 51 tuberculous pleurisy cases,30 malignant pleurisy cases and 20 non-tuberculous pleurisy cases by ELISA.Results There was a significant difference of interferon-γ levels different groups.The levels in tuberculous pleurisy group was 58.75±70.89 pg/ml.It is higher than that in other two groups ( P <0.01).The levels in group of malignant pleurisy was 54.64±36.67 pg/ml and in the group of non-tuberculous pleurisy was 58.75±47.26 pg/ml.Conclusion The levels of interferon-γ could be an important reference indicator for diagnosis of tuberculous pleurisy.