期刊文献+

新鲜羊膜移植治疗单纯疱疹病毒性角膜炎的初步研究 被引量:2

A clinical study on fresh amniotic membrane transplantation for herpes simplex keratitis
下载PDF
导出
摘要 目的:探讨新鲜羊膜移植治疗单纯疱疹病毒性角膜炎的可行性、手术方法和治疗效果。方法:对本院收治的23例单纯疱疹病毒性角膜炎患者(25眼)进行羊膜移植,手术方法有:单层羊膜覆盖术18例(20眼),多层羊膜移植术5例(5眼)。术后随访6~12mo。结果:术后均未见新鲜羊膜植片急性排斥反应。术后3~15d炎症得到迅速有效的控制,眼部刺激症状消失,睫状体充血消退。视力有不同程度的提高。结论:对单纯疱疹病毒性角膜炎进行新鲜羊膜移植可以有效的控制炎症,迅速减轻局部症状,重建眼表,缩短病程,防止严重并发症的发生。 AIM: To evaluate the feasibility, operation methods and efficacy of fresh amn iotic membrane transplantation (AMT) for herpes simplex keratitis.· METHODS: Amniotic membrane transplantation was performed on23 cases (25 eyes ) of herpes simplex keratitis, including monolayer amniotic membrane patch (18 c ases, 20eyes ) and multilayer AMT (5 cases, 5 eyes). All patients were followed up for 6-12mo.· RESULTS: No acute rejection was observed after AMT. The infection and inflamm ation was effectively controlled within 3-15d, the irritations of eyes disappear ed, and ciliary bodies hyperemia regressed. Visual acuity was improved to variou s degrees.· CONCLUSION: Transplantation of fresh amniotic membrane can effectively contro l inflammation, relieve local symptom rapidly, rebuild the ocular surface, short en course and prevent serious complications.·
出处 《国际眼科杂志》 CAS 2004年第4期759-761,共3页 International Eye Science
关键词 羊膜 移植 角膜炎 单纯疱疹病毒 amnion transplantation keratitis viral herpes simplex virus
  • 相关文献

参考文献11

  • 1李凤鸣.眼科全书(第1版)[M].北京:人民卫生出版社,1996.1932.
  • 2Solomon A, Rosenblatt M, Monroy D. Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix. Br J Ophthalmol, 2001;85:444-449
  • 3Keadle TL, Usui N, Laycock KA. IL-1 and TNF-alpha are important factors in the pathogenesis of murine recurrent herpetic stromal keratitis. Invest Ophthalmol Vis Sci, 2000;41:96-102
  • 4Bultmann S, You L, Spandau V. Amniotic membrane downregulates chemokine expression in human keratocytes. Invest Ophthalmol Vis Sci,1999:40:578
  • 5Shimazaki J, Yang HY, Tsubota K. Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal bums.Ophthalmology, 1997;104:2068-2076
  • 6Sato H, Shimazaki J, Shinozaki N. Role of growth factors for ocular surface reconstruction after amniotic membrane transplantation. Invest Ophthalmol Vis Sci, 1998;39:428
  • 7Fukuda K. Differential distribution of subchains of the basement membrane components type V collagen and laminin among the amniotic membrane,cornea, and conjunctiva. Cornea, 1999;18:73-79
  • 8Koizumi NJ, Inatomi TJ, Sotozono CJ. Growth factor mRNA and protein in preserved human amniotic membrane. Curr Eye Res, 2000;20:173-177
  • 9Touhami A, Grueterich M, Tseng SC. The role of NGF signaling in human limbal epithelium expanded by amniotic membrane culture. Invest Ophthalmol Vis Sci, 2002;43:987-994
  • 10Heiligenhaus A, Bauer D, Meller D. Improvement of HSV-1 necrotizing keratitis with amniotic membrane transplantation. Invest Ophthalmol Vis Sci,2001 ;42:1969-1974

二级参考文献3

共引文献78

同被引文献12

  • 1梁宝铎,曾真,赵祥胜.乙型肝炎血清学标志间非特异性交叉反应的研究[J].中华医学检验杂志,1995,18(4):232-235. 被引量:45
  • 2谢立信.角膜病的基础研究进展.中华医学会继续医学教育教材-眼科学新进展,2004:11-17
  • 3陈家祺.角膜眼表疾病临床诊治的进展.中华医学会继续医学教育教材-眼科学新进展,2004:18-30
  • 4Koelle DM,Ghiasi H.Prospects for developing an effective vaccine against ocular herpes simplex virus infection.Curr Eye Res,2005;30(11):929-942
  • 5Koelle DM.Vaccines for herpes simplex virus infection.Curr Opin Investig Drug,2006;7(2):136-141
  • 6Keadle TL,Morris JL,Stuart PM.The effects of aminoguanidine on primary and recurrent ocular herpes simplex virus infection.Nitric Oxide,2005;13(4):247-253
  • 7Keadle TL,Usui N,Laycock KA,Kumano Y,Pepose JS,Stuart PM.Cytokine expression in murine corneas during recurrent herpes stromal keratitis.Ocul Immunol Inflamm,2001 ;9(3):193-205
  • 8Sugioka K,Drake JD,Hwang DG,Fukuda M,Shimomura Y.Susceptibility of human corneal endothelial cells to HSV-1 infection.Curr Eye Res,2005;30(10):863-869
  • 9Wood D J, Cobitt G. Viral infections in childhood leukemil [J]. J Inf Dis, 1985 , 152(2) :266-273.
  • 10The Quality of Medicine of the Council of Europe. Human varicella immunoglobulin 01/2005:0724 European Pharmacopoeia 5th edition Volume 2.2004:1752-1753.

引证文献2

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部