口服避孕药对二乙基亚硝胺诱发大鼠肝癌癌前病变的影响

EFFECT OF ORAL CONTRACEPTIVE ON PRENEOPLASTIC LESIONS OF HEPATOMA INDUCED BY DIETHYLNITROSAMINE

采用大鼠腹腔注射单剂量二乙基亚硝胺(DEN)作为启动剂结合部份肝切除的短期实验模型,观察复方十八甲基炔诺酮对肝癌癌前病变的影响。实验结果发现单剂量DEN冲击后,再投以复方十八甲基炔诺酮的大鼠,其肝组织γ-GT(+)灶的面积、体积、数量(mm^2/个、mm^3/个、mm^2/cm^2、个/cm^2和个/cm^3)均高于单纯受DEN冲击的大鼠。提示复方十八甲基炔诺酮具有促肝癌作用。另外,若以生理盐水代替DEN,再投以复方十八甲基炔诺酮的大鼠,实验始终未出现γ-GT(+)灶,表明复方十八甲基炔诺酮无启动肝细胞的致癌作用。

Rats injected intrapcritoeally with a single dose of hepatoma induced by diethylnitrosamine(DEN)as initiating agent in association with a partial(two-thirds) hepatectomy was used as a short-term experimental model in this study.The effect of Norgestrel Compound Long-acting Oral Contraceptive Tab.(OC)on preneoplastic lesions of hepatocarcinogenesis was studied.The results indicated that the area, volume,and quantity of γ-GT positive loci of rats given OC after a single dose of DEN were greater than that of rats given DEN alone.These suggest that OC is an enhancer of the appearance of preneoplastic lesions of hepatocarcinogenesis.The results also indicated that the rats given OC along didn′t manifest any γ-GT positive foci.This suggests that OC is not an initiating agent.The mechanism of OC in hepatocarcinogenesis remains unclear.