温州市狂犬病新发疫源地的流行病学调查

Epidemiological investigation of rabies in a new epidemic area in Wenzhou City, Zhejiang Province.

目的 研究狂犬病新发疫源地的流行特征、动物传染源的感染状况及其在狂犬病流行中的作用等。 方法 在温州市狂犬病新发疫源地 ,采用现场流行病学调查及对疫区动物作病理学解剖和脑组织镜检观察等。 结果 2 0 0 0年 12月发生温州市首例狂犬病病例 ;其动物传染源来自狂犬病新发疫源地 ;动物传染源为犬和猫 ;从犬中检出Negri小体 ;犬中虽存在Negri小体 ,但并未发病 ,而呈隐性感染。 结论 温州市为狂犬病新发疫源地 ;检测动物Negri小体有助于狂犬病临床诊断和确定人间狂犬病疫情 ,并可监测动物中狂犬病流行 ,对预测狂犬病发病趋势和人狂犬病防制工作有重要意义。

Objective To investigate the epidemiological characteristics of rabies in a new epidemic area, infectious status of animal reservior and their role in a rabies epidemic. Methods A field epidemiologic investigation in an epidemic area was carried out in Wenzhou, Zhejiang, China. Pathogenic anatomy and a microscopic examination for Negri bodies in brain tissue post mortem of a dog were conducted. Results The first case of rabies found in Wenzhou in December 2000. An animal reservoir originated from a new epidemic area of rabies. Both a dog and a cat were confirmed to be animal reservoir in Wenzhou. Negri bodies were found in the brain tissues of the dog. Although the onset of the disease did not occur, the dog presented with status of latent infection. Conclusion A new epidemic area of rabies was identified in Wenzhou. Detection of Negri bodies will be helpful for clinical diagnosis of rabies, determination of a confirmed rabies case in humans. Detection of Negri bodies is beneficial to surveillances of rabies in animals, forecasts of epidemic trends of rabies, and control and prevention of rabies in humans.