不同浓度氧气对高原失血性休克动物疗效的影响

Experimental Study of Different Concentrations of Oxygen in Treatment of High Altitude Hemorrhagic Shock

目的 探讨氧疗在高原失血性休克救治中的疗效 ,以及理想的氧气治疗浓度。方法 采用高原失血性休克兔模型 ,设计给氧 +补液 (Ⅰ、Ⅱ、Ⅲ组 )、给氧 (Ⅳ组 )和补液 (Ⅴ组 ) ,休克 1h后进行治疗 ,观察其生命体征和存活时间。结果 平均动脉压回升Ⅰ、Ⅱ组 2个、Ⅲ组 1个时相点与Ⅳ组有差异 ,P <0 .0 5 ;中心静脉压回升Ⅰ组与Ⅳ、Ⅴ组比较 ,P <0 .0 1;尿量增加Ⅰ、Ⅱ组S3 与S2 比较 ,P <0 .0 1;存活时间Ⅰ组与Ⅳ、Ⅴ组比较P <0 .0 1、与Ⅱ组比较P <0 .0 5 ;8h以上存活率Ⅰ组为 2 8.5 7% ,其余组为 0 %。结论 氧疗是高原失血性休克救治中必不可少的护理措施 ,给氧浓度越高 。

Objective To investigate the curative effect in treatment of hemorrhagic shock at high altitude environment and the better concentration of oxygen therapeutics.Methods The rabbits model of high altitude hemorrhagic shock was used. Animals were divided into transfusion and oxygen therapy (groups Ⅰ,Ⅱ,Ⅲ), oxygen therapy (group Ⅳ) and transfusion (group Ⅴ) groups . The therapeutic managements were performed 1h after shock. The physical signs and the survival time of animals were recorded.Results There were significant difference among groups Ⅰ,Ⅱ,Ⅲ and groups Ⅳ in MAP values ( P <0.05) and among group I and groups Ⅳ, Ⅴin CPV values ( P <0.01). The urine quantity of animals in groups Ⅰand Ⅱ increased obviously compared with that at 1h after shock ( P <0.01). The survival times of animals in groups Ⅰwere longer than that in groupsⅡ, Ⅳ and Ⅴ. The survival rate that animals stayed alive more than 8h in groupⅠwas 28.57% and was 0 in other groups.Conclusions The oxygen therapy is a necessary nursing management in the process of treating high altitude hemorrhagic shock.More concentration of oxygen inhaled, better curative effect obtained.