2型糖尿病患者骨密度改变的多因素分析

Muiti factor analysis changes bone mineral density in patients with type 2 diabetes mellitus

目的 探讨 2型糖尿病老年患者骨密度改变 ,以了解 2型糖尿病患者骨质疏松与其相关影响因素的关系。方法 采用双能X线骨密度仪 ,测定 2型糖尿病老年男性患者 30例、女性患者75例 ,按女性骨密度是否出现骨质疏松分为骨质疏松组与无骨质疏松组 ,并根据年龄、病程、绝经年限、体重指数、性激素、钙、碱性磷酸酶进行比较及相关性分析。结果 女性骨质疏松组年龄较大、绝经年限延长、孕酮水平低 ;骨密度无论男女与其病程呈负相关 ,与体重指数呈正相关关系 ;男女腰椎体以L1骨密度最低。结论 2型糖尿病患者绝经后时间越长则越易发生骨质疏松 ,体重指数和性激素减低加重骨密度丢失。

Objective To investigate the relationship between changes in bone mineral density and contributory factors in old patients with type 2 diabetes mellitus. Methods Lumber vertebral bone mineral densities in 30 old male and 75 old female patients with type 2 diabetes were measured by dual energy X-ray absorptiometry, and divided into osteoporotic (OP)group and non-osteoporotic (NOP) group in the 75 female diabetic patients according to existence or not of osteoporosis, and various factors such as age, course of diease, duration of menopause, body mass index(BMI), sexual hormone, calcium, and alkaline phosphatase werw compared between OP group and NOP group and anakad. Results The parameters of age, duration of menopause, and progesterone were factors influenciag of occurrence steoporosis, and the bone mineral densities in old male and female patients with type 2 diabetes were negatively correlated with course of disease and positively correlated with body mass index. Bone mineral density values of the first lumbar vertebra (L 1) were lowest in old men and women. Conclusion The incidence of osteoporosis increases with increasing duration of menopause. Declinein body mass index or sexual hormone will aggravate bone mineral loss.