益盖宁对骨质疏松并心瓣膜钙化老年人腰背疼痛的改善作用

Effect of elcitonin on alleviation of backache in old patients with osteoporosis and calcified cardiac valve

目的 观察益盖宁对骨质疏松并心瓣膜钙化老年人腰背痛改善及对骨吸收指标尿脱氧吡啶啉的抑制作用。方法 71例经二维超声心动图证实有心瓣膜钙化 ,X线有骨质疏松改变的老年人 ,予益盖宁 2 0U肌注 ,每周 1次 ,共 2 4周 ,并合用钙尔奇D。治疗前后测定尿脱氧吡啶啉。结果 治疗 4周后腰背疼痛明显缓解 ,治疗 8周后腰背疼痛消失或明显改善 ,止痛效果可持续至疗程结束 ,总有效率为 94 3%。治疗后尿脱氧吡啶啉较治疗前明显下降 ,统计学差异有非常显著性 (P <0 0 0 1)。结论 益盖宁显著改善骨质疏松并心瓣膜钙化老年人腰背痛 ,能降低尿脱氧吡啶啉 ,提示对骨吸收有一定抑制作用。

Objective To study the effect of elcitonin on alleviation of backache in old patients with osteoporosis and calcified cardiac valve and on its in hibition of urine deoxypyridinoline. Methods 71 elderly patients had calcified cardica valve demonstrated two-dimensional echocardiogram and osteoporosis evidenced by X-rays. These patients were treated by intra muscylar injection of 20u elcitonin once a week for 24 weeks, combined with oral Caltrate-D verry day. Urine deoxypyridinoine was defermined before and after treatment. Results Backche of the old patints was allayed after 4 weeks of treatment, and subdued or relived markedly after 8 weeks of treatment. The analgesic effect was mainfained till the end of the treatment course. 94.3% of the patients had excellent or good response. The urine deoxypyridinoline level decreased significantly after treatment, compared with before treatment (P<0.001). Conclusions Elcitonin markedly alleviates osteoporotic backache of old patients with calcified cardiac valve and lowers the level of urine deoxypyridinoline. It is suggested that elcitonin inhibits bone absorption to some extent.