摘要
Objectives To study the geneexpression of human vascular endothelial cells (HU-VEC) treated by ouabain in pathological concentra-tion. Methods The response of endothelial cells toouabain of 1.8 nmol/L was explored with a comple-mentary DNA microarray representing 8 464 differenthuman genes. Results The results of mRNA profilesanalysis indicated that 129 of the genes were differ-ently expressed, 26 were upregulated. ConclusionsThe pathological role of ouabain on HUVEC may beinvolved in the controlling of DNA transcription、pro-tein translation、metabolism and signal transduction.
Objectives To study the geneexpression of human vascular endothelial cells (HU-VEC) treated by ouabain in pathological concentra-tion. Methods The response of endothelial cells toouabain of 1.8 nmol/L was explored with a comple-mentary DNA microarray representing 8 464 differenthuman genes. Results The results of mRNA profilesanalysis indicated that 129 of the genes were differ-ently expressed, 26 were upregulated. ConclusionsThe pathological role of ouabain on HUVEC may beinvolved in the controlling of DNA transcription、pro-tein translation、metabolism and signal transduction.
