β-catenin在胰腺癌中表达的意义

Significance of β-Catenin Expression in Pancreatic Carcinoma

目的 探讨 β catenin(连环素 )在胰腺癌表达的临床意义。 方法 对手术切除的 4 6例胰腺癌标本进行免疫组化染色 ,检测β catenin在胰腺癌中的表达 ,并分析其和胰腺癌的分级、分期以及有无转移等指标的关系。结果 β catenin在胰腺癌细胞膜的异常表达率为 5 4 .3% ,且分化越差则在细胞膜的异常表达率越高 ,有转移者高于无转移者 ;其在细胞浆的异常表达率为 2 1.7% ,与胰腺癌的分化、分期及有无转移无显著相关性 ,但 2 3例术前介入化疗的患者中 ,肿块缩小者 ( 14例 )在细胞浆的异常表达率为 0 ,显著低于 9例肿块无缩小者的 33.3% ;β catenin在细胞膜和细胞浆异常表达具有一致性 ,为 6 3.0 %。结论 β catenin在细胞膜的异常表达能促进肿瘤转移 。

Objective To explore the clinical significance of β catenin expression in pancreatic carcinoma.Methods The immunohistochemical staining was performed to detect the expression of β catenin in the specimens of 46 patients with pancreatic carcinoma and the results were statistically analyzed. Results The abnormal expression rate on the membrane was 54.3%, the poorer the differentiation, the higher the abnormal expression rate. The levels of the cases in whom metastasis occurred were much higher than those without metastasis. The abnormal cytoplasm expression rate was 21.7%,which had not significant correlation with the clinical indexes, such as staging, tumor size, grading and metastasis. In 23 patients who accepted intervention chemotherapy before operation, the cytoplasm expression rate in those with tumor mass smaller was 0, which was evidently lower than that of those without tumor mass change (33.3%). Moreover, the abnormal membrane and cytoplasm expression rates had remarkable concordance (63.0%).Conclusion The abnormal membrane expression of β catenin may accelerate metastasis, and the abnormal expression of β catenin in cytoplasm may result in cell proliferation.