氯沙坦、培多普利对大鼠急性心肌梗死后心室重构及血流动力学的干预作用

Effects of losartan and perindopril on ventricular remodeling and left ventricular function after AMI in rats

目的观察氯沙坦、培多普利对大鼠急性心肌梗死(AMI)后心脏大体形态和血流动力学的影响。方法 结扎左冠状动脉法制作AMI模型,随机分为对照组(C);氯沙坦组(L);培多普利组(P);氯沙坦加培多普利组(LP);假手术组(S)。6周后观察心脏长径、周径、左心室重量、心率、血压、左心室收缩压(LVSP)、左心室舒张末期压(LVEDP)和±ap/at等指标。结果①3个用药组的动脉收缩压(SBP)、舒张压(DAP)和动脉平均压(MBP)及LVSP显著低于S和C组(P<0.01及P<0.05);②与S组比较,C组(P<0.001)和3个用药组(P<0.05)的LVEDP显著增高,而±dp/dt(P<0.01)显著降低,且3个用药组的LVEDP明显低于C组,而±dp/dt显著高于C组(P<0.01);③C组的心脏长径、周径、左室重量及左室重量指数显著高于S组和3个用药组(均P<0.05)。结论氯沙坦、培多普利可以减轻左室重构,改善心功能障碍。

OBJECTIVE: To investigate the effects of losartan and perindopril on ventricular remodeling and left ventricular function after AMI in rats. METHODS: Animal models of AMI were made in rats and randomly divided into 5 groups: sham-operated group (S), control (C), losartan treatment (L), perindopril treatment (P), and combined treatment (LP). After 6 weeks, the heart length, periphery, left ventricular weight, heart rate, blood pressure, left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP) and ± dp/dt were measured. RESULTS: The SBP, SDP, MAP and LVSP were significantly decreased in all the treated groups (P < 0.01 or P < 0.05). Compared with S group, LVEDP was significantly increased in C (P < 0.001) and the treated groups (P < 0.05), ± dp/dt was significantly decreased (P < 0.01). LVEDP in the treated groups was lower than that in C group (P < 0.01). ± dp/dt in the treated groups was higher than that in C group (P < 0.01). The heart length and periphery and left ventricle weight were significantly increased in C groups (P < 0.05). CONCLUSION: Losartan and Perindopril could improve the left ventricular remodeling and heart functions in AMI rats.