阿替洛尔鼻用凝胶剂在兔体内的药动学

Pharmacokinetics of atenolol gel for nasal administration in rabbits

目的通过对阿替洛尔凝胶在家兔体内的药动学研究,评价阿替洛尔凝胶剂作为鼻腔给药系统的应用价值及作用。方法取12只家兔随机分为两组,分别进行鼻腔给药和口服片剂给药,采用反相高效液相色谱法测定家兔血浆中阿替洛尔的浓度,并用3P97程序软件处理,用t检验法进行显著性检验。结果鼻腔给药的阿替洛尔凝胶吸收速度快,相对生物利用度达109.71％。结论阿替洛尔鼻用凝胶剂生物利用度有所提高,个体差异小。

OBJECTIVE: To investigate the practicability of atenolol gel as a nasal dilivery system by the study of its pharmacokinetics in rabbits. METHODS: Twelve rabbits were divided into two groups randomly. The fate of atenolol in the plasma of rabbits was followed after nasal and oral administration of 25 mg of atenolol. Atenolol in plasma was determined by RP-HPLC. The concentration-time data was fitted using 3P97 pharmacokinetic program and the pharmacokinetic parameters were compared by i-test. RESULTS: The absorption rate of the nasal gel was faster than that of the oral tablets. The relative bioavailability of atenolol nasal gel was 109.71 % . CONCLUSION: The atenolol nasal gel had better bioavailability than oral tablets with small difference between individuals.