冷水七不同溶剂提取物对小鼠疼痛的影响

Effect of Different Extracts of Lmpatiens Omeiana on Pain in Mice

目的 研究冷水七不同溶剂提取物对小鼠疼痛的影响 ,并确定其镇痛作用的有效部位。方法 镇痛实验采用热板法和扭体法 ,观察灌胃不同剂量的冷水七不同溶剂提取物后小鼠的痛阈值和扭体反应的次数。结果 冷水七正丁醇提取物高、低剂量组小鼠痛阈值明显增加 ,扭体次数明显减少 (p <0 0 1 )。结论 冷水七正丁醇提取物对小鼠具有明显镇痛作用 。

Objective To study the effect of different extracts of Lmpatiens Omeiana Hook.f.on pain in mice and identify the effective constituents.Methods The pain-killing effect was test by hot plate model and body twisting model induced by acetic acid in mice.Results ln the mice administered with high or low dose of n-BuOH extracts,the pain threshold was increased and the twisting number was markedly reduced(P<0.01).ConlusionThe n-BuOH extracts of lmpatiens Omeiana have pain-killing effect in mice and seems to be the effective constituent of Lmpatiens Omeiana.