淮安市伤寒Vi抗体阳性率调查研究

Survey on the positive rate of Salmonella typhoid Vi-antibody in Huaian city

目的 为了解淮安市伤寒Vi抗体的阳性率并借此搜索慢性带菌者。方法 淮安市疾病预防控制中心于 1999年 4～5月间 ,采用间接血凝 (PHA)法检测 64 3名调查对象血清中Vi抗体 ,以 1∶3 2为阳性滴度则阳性率为 0 .93 3 % ,以抗体滴度的常用对数为因变量 ,以地区、性别、年龄、职业、病史、免疫接种史为自变量作多元线性回归分析向后法进行分析。结果 抗体滴度与地区、病史、免疫接种史 3个因素间有显著的统计学意义。以 1∶8为抗体阳性界限作为因变量 ,以地区、性别、职业、病史、免疫接种史为自变量 ,作向后法逐步logistic回归分析 ,结果表明抗体阳性率与地区及免疫接种史之间有非常显著统计学意义 ,而与性别、职业、病史无显著统计学意义。

To learn the positive rate of Salmonella typhoid Vi-antibody in Huaian city and to search chronic bacteria carriers. The Vi-antidody in serum of 643 objects was surveyed with PHA during Aril to May of 1999. When titer 1:32 is taken as positive, the positive rate was 0.933%. Retrospective analysis was made with the common logarithm of the antibody titer being taken as dependent variable, and region, gender, age, occupation, medical history and inoculation history being taken as independent variables. Great statistic significance was found between antibody titer and region, medical history and inoculation history. The logistic retrospective analysis conducted under the condition of titer 1∶8 being taken as positive and served as dependent variable, and region, sex, occupation, medical history, inoculation history being taken as independent variables indicated that there was great statistic significance between antibody positive rate and region and inoculation history but not with gender, occupation, and medical history. [Conclusion] It is not very effective to apply PHA method in searching chronic bacteria carriers.