L-肉碱治疗附睾结节伴弱精子症初步观察

Initial Observation on L-carnitine for Asthenospermia with Epididymal Knob

目的 :评价L 肉碱治疗附睾结节伴弱精子症患者的疗效。 方法 :2 0 0 3年 5月～ 2 0 0 4年 7月至我院男科门诊就诊的 35例附睾结节伴弱精子症患者 ,年龄 2 5～ 39岁 ,平均 31岁。口服L 肉碱口服溶液 ,1.0 g/次 ,2次 /d ,共3个月。分别于治疗前及治疗 3个月末 ,采用DNA荧光染色精子动 (静 )态图像分析系统进行精液参数分析。 结果 :完成治疗的 32例患者中 ,除 4例精液质量未见明显改善外 ,其余 2 8例精液质量均明显改善。其中 ,除精子密度治疗前后差异无显著性外 (P >0 .0 5 ) ,前向精子活动率、总活动率、曲线运动速度、直线运动速度以及平均轨迹速度等主要精液参数指标 ,在L 肉碱治疗 3个月后均有显著改善 (P均 <0 .0 1)。治疗期间及治疗后随访 2个月内有 4例配偶怀孕 ,其中 1例已正常分娩。 结论 :L 肉碱对附睾结节伴弱精子症具有较好的疗效。

Objective: To evaluate the efficacy of L-carnitine on asthenospermia with epididymal knob. Methods: Thirty-five patients aged 25 ～ 39 years with asthenospermia with epididymal knob were received at our clinic of andrology from May 2003 to July 2004, and given oral L-carnitine 2 g/d for 3 months. The sperm parameters of the patients were analyzed by computer-assisted sperm analysis system before and after L-carnitine treatment. Results: Of the 32 patients who accomplished the 3-month L-carnitine therapy, only 4 remained unimproved in sperm parameters, while the other 28 were significantly improved in sperm concentration, forward sperm motility, total sperm motility, straight line velocity, curvilinear velocity and average path velocity. Four of the patients' wives were pregnant and one patient fathered a child. Conclusion: Oral L-carnitine therapy is efficacious for asthenospermia with epididymal knob.