少精子症患者血清、精浆中游离睾酮水平的测定及意义

Detection of Free Testosterone in the Serum and Semen of Idiopathic Oligospermia Patients and Its Significance

目的 :通过测定少精子症患者血清、精浆中游离睾酮 (FT)水平 ,分析血清、精浆FT与少精子症的关系。 方法 :正常对照组 (n =4 4 )、少精子症组 (n =4 4 )男性于上午 8:0 0～ 10 :0 0留取血标本 ;正常对照组 (n =30 )、少精子症组 (n =37)同时留取精液。男性精液常规分析判断精子密度 ,放射免疫分析法测定血清、精浆中FT水平。 结果 :少精子症患者血清中FT浓度为 [(94 .88± 4 2 .0 4 )pmol/L],与正常对照组 [(97.5 0± 4 6 .96 )pmol/L]相比差异无显著性 (P >0 .0 5 ) ,但少精子症患者精浆中FT浓度 [(0 .5 2± 0 .4 4 ) pmol/L]显著低于正常对照组 [(2 .0 1±0 .32 )pmol/L],P <0 .0 1。 结论 :精浆中FT的测定较早反映睾丸的功能 ,有利于少精子症患者的早期诊断和治疗。

Objective: To detect free testosterone (FT) in the serum and semen of patients with idiopathic oligospermia, and further analyze the relationship between FT and idiopathic oligospermia. Methods: Blood samples were collected from the males of a normal control group(n=44) and an idiopathic oligospermia group(n=44) at 8:00～10:00 a.m.. Semen samples were collected from the males of a normal control group(n=30) and an idiopathic oligospermia group(n=37) at the same time. Sperm density was detected by routine semen analysis, and FT in the serum and semen was detected by RIA. Results: There was no significant difference in the serum concentrations of FT between the groups of normal control[ ( 97.50± 46.96) pmol/L] and idiopathic oligospermia [( 94.88± 42.04) pmol/L],P> 0.05. But the difference was significant in the semen concentrations of FT between the groups of normal control [( 2.01± 0.32) pmol/L] and idiopathic oligospermia [( 0.52± 0.44) pmol/L], P< 0.01. Conclusion: Measurement of semen FT concentration could early reflect the function of the testis, which contributes to the early diagnosis and treatment of idiopathic oligospermia.