环胞菌素A治疗难治性贫血7例临床观察

Clinical Report on Treatment of 7 Patients with Refractory Anemia by Using Cyclosporin A

为了探讨难治性贫血治疗 ,对 7例骨髓增生异常综合征 (难治性贫血亚型 )患者 ,应用环胞菌素A(CsA)和康力龙进行了治疗 ,CsA用药时间为 5个月至 3年 ,平均为 13个月。结果表明 :6例治疗有效 ,1例无效。治疗有效的 6例中 3例完全缓解 ,不依赖输血 ,1例获得部分缓解 ,2例有所好转。治疗好转时间为 1- 5个月 ,平均为 3 5月。在观察期间所有病例无白血病或其它肿瘤临床表现。结论 :环胞菌素A对部分难治性贫血病例有效 ,患者对毒副作用可耐受 ,值得进一步观察应用。

To explore the treatment of refractory anemia (RA), 7 cases of myelodysplastic s yndrome (subtype of refractory anemia) were treated in combination of cyclosporin A (CsA) with st anozolol. Duration of treatment with CsA was 5 months - 3 years (mean 13 months ). The results showed that anmong 7 cases 6 were effective, 1 case no responded to treatment. 3 cases out of 6 effective cases achieved complete remission with out transfusion dependence, 1 cases achieved partial remission, 2 cases were imp roved. During the investigation signs of leukemia ot other malignant tumors not were found in all cases. In conclusion, CsA treatment is effective for part cas es of RA, side effects of drugs are tolerable for patients.