老年肿瘤患者化疗后急性粒细胞缺乏症的救治

The treatment of acute agranulocytosis in the aged patients with tumor after receiving chemotherapy

目的 探讨老年肿瘤患者化疗后急性粒细胞缺乏症的救治方案。方法 回顾性分析某院 15例化疗后发生急性粒细胞缺乏的老年肿瘤患者的病历资料。结果 通过给予保护性隔离、强有力的抗菌药物、造血生长因子以及积极的支持治疗等措施 ,使 14例 (93.33% )患者救治成功 ,发热症状在 3～ 11d得到控制。结论 老年肿瘤患者化疗后出现粒细胞缺乏症时 ,在应用强有力广谱抗菌药物治疗的同时 ,应防止患者合并真菌感染 ;并应积极控制局部感染灶 ,应用粒细胞集落刺激因子促进白细胞恢复 ,加强支持治疗。

Objective To evaluate the treatment of acute agranulocytosis in the aged patients with tumor after receiving chemotherapy. Methods Clinical data of 15 patients with tumor after receiving chemotherapy in a hospital were analysed retrospectively. Results Fourteen patients ( 93.33% ) were brought out of danger after receiving protective isolation, effective antimicrobial agents, hematopoietic growth factor and active supportive treatment, fever was controlled within 3-11 days. Conclusion When the aged patients with tumor after receiving chemotherapy had agranulocytosis, effective antimicrobial agents and antifungal should be given to prevent infection with fungi; local infection foci should be controlled; granulocyte colony stimulating factors can be applied to promote the recovery of leukocytes, supportive treatment should be strengthened.