原发性高尿酸血症治疗的必要性和血清镁的变化

Necessity to treat patients with primary hyperuricemia accompanied with variation in serum magnesium

目的 以血清镁离子浓度作标记 ,观察血清镁的变化 ,探讨原发性高尿酸血症治疗的必要性。方法 将 75例原发性高尿酸血症患者分为两组进行 5年随诊 ,观察血清镁离子、血糖、血脂、血肌酐、血尿酸、血压变化及并发症发生情况。结果 治疗组半年时随血尿酸浓度下降血清镁也下降 (P <0 .0 1) ,且与非治疗组差别明显 (P <0 .0 1) ,而非治疗组无变化 (P >0 .0 5 )。非治疗组 2型糖尿病、高脂血症、肾损害、痛风性关节炎急性发作 5年时发生率明显高于治疗组 (P <0 .0 5 )。结论 原发性高尿酸血症有治疗的必要性 ,且伴有血清镁升高 。

Objective To reveal the necessity to treat patients with primary hyperuricemia accompanied with variation in serum magnesium.Methods Seventy-five patients with primary hyperuricemia were divided into trail group - with treatment and control group-without treatment and a 5-year follow-up was carried out.The changes in serum magnesium ions,blood sugar,blood fat,blood inosine,blood uric acid and blood pressure as well as development of complications were observed.Results The results showed that after half a year of treatment,the concentrations of serum magnesium ions and of blood uric acid in the trail group decreased significantly(P<0.01),while no changes were observed in control group(P>05);and with a significant difference between these two groups(P<0.01).During the five-year period of follow-up,the developing rates of type-2 diabetes mellitus,hyperlipemia,renal damage and acute occurrence of arthrolithiasia in control groups were significantly higher than those in trail group(P< 0.05).Conclusion It is necessary to treat patients with primary hyperuricemia, accompanied with the increase of serum magnesium ions level, which was related to soft tissue damage.