摘要
用对甲氧基苯乙腈和环已酮在氢化钾/甲苯中进行缩合反应得到a-(1-羟基环己基)-对甲氧基苯乙腈,再经Red-Al或NiCl2/NaBH4还原、甲基化等反应制得盐酸文拉法辛,总收率为50%~62%。
Venlafaxine hydrochloride was synthesized from 4-methoxybenzyl cyanide and cyclohexanone bycondensation in presence of KH in toluene to give a-(1-hydroxycyclohexyl)-4-methoxybenzyl cyanide, which subjectedto reduction by Red-Al or NiCl2/NaBH4 and subsequent methylation with an overall yield of 50%~62%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第10期577-578,共2页
Chinese Journal of Pharmaceuticals
关键词
文拉法辛
抗抑郁药
合成
venlafaxine
antidepressant
synthesis