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核磁共振技术(NMR)在组合化学中的应用

Applications of Nuclear Magnetic Resonance Spectroscopy (NMR) to Combinatorial Chemistry
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摘要 对科学产生最大影响的分析方法是核磁共振技术 (NMR) ,它被广泛用于许多领域。本文结合作者的研究结果评述了NMR在组合化学中的应用 ,着重于NMR在固相合成的应用、液态NMR和NMR在高通量筛选中的应用。 The analytical method that has the greatest impact on science is nuclear magnetic resonance spectroscopy. It is widely used in many fields. Combining author's research, the applications of nuclear magnetic resonance spectroscopy (NMR) to combinatorial chemistry, including applications of NMR to solid phase synthesis, analysis in solution and screening by NMR are reviewed.
作者 姚念环 贺文义 刘刚 Kit S.LAM
机构地区 中国医学科学院中国协和医科大学药物研究所 University of California
出处 《化学进展》 SCIE CAS CSCD 2004年第5期696-707,共12页 Progress in Chemistry
关键词 核磁共振技术 组合化学 固相合成 高通量筛选 nuclear magnetic resonance spectroscopy solid phase synthesis solution state NMR high throughput screening
分类号 O641.3 [理学—物理化学] O657.2 [理学—分析化学]
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参考文献74

  • 1Paabo S. Science, 2001, 291: 1219-1220
  • 2Ferenc D, Gyorgy D, Laszlo U, et al. Pure and Applied Chemistry, 2001, 73(9): 1487-1498
  • 3Araujo D R L, Arlene G C. Quim. Nova., 2001, 24(2): 236-242
  • 4Baldino C M. J. Comb. Chem., 2000, 2(2): 89-103
  • 5Geysen H M J, Meloen R H, Barteling S J. Proc. Natl. Acad. Sci. USA, 1984, 81: 3998
  • 6Furka A, Sebestyen F, Asgedom M, et al. In Highlights of Modern Biochemistry, Proceeding of the 14th International Congress of Biochemistry, VSP. Utrecht, The Netherlands, 1988, 5:47
  • 7Devlin J J, Panganiban L C, Devlin P E. Science, 1990, 249: 404
  • 8Edward P J. Combinatorial Chemistry & High Throughput Screening, 2003, 6: 11-27
  • 9Merrifield R B. J. Am. Chem. Soc., 1963, 85: 2149-2154
  • 10Epton R, Goddard P, Ivin K J. Polymer Commun., 1980, 21: 1367-1371

二级参考文献16

  • 1刘刚 萧晓毅 印刷中.新药研究中的组合化学[M].北京：科学出版社,..
  • 2MacBeath G, Koehler A N, Schreiber S L. Printing Small Molecules as Microarrays and Detecting Protein-Ligand Interactions en Masse[J]. J Am Chem Soc, 1999, 121: 7967.
  • 3Maly D J, Choong I C, Ellman J A. Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors[J]. Proc Natl Acad Sci, USA, 2000, 97(6): 2419.
  • 4Staunton J, Weissman K J. Polyketide biosynthesis: A millennium review[J]. Nat Prod Rep, 2001, 18(4) :380.
  • 5Barbara T M. Cylindrical demagnetization fields and microprobe design in high-resolution NMR[J]. J Magn Reson SeriesA, 1994, 109: 265.
  • 6Fuks L F. Susceptibility, lineshape, and shimming in high-resolution NMR[J]. J Mag Reson, 1992, 100:229.
  • 7Liu G, Lam K S. Practical Approach: Combinatorial Chemistry[M]. Edited by Fenniri H. New York: Oxford University Press 2000. P33.
  • 8Castro-Palomino J C. Synthesis Of Aryl C-Glycosides of Glucosamine Liebigs Ann[J], 1996, 1623.
  • 9Keifer P A. A Comparison if NMR Spectra Obtained for Sohd-Phase-Synthesis Resins Using Conventional High-Resolution, Magic-Angle-Spinning, and High-Resolution Magic-Angle-Spinning Probes[J]. J Magn Reson Series A,1996, 11: 65.
  • 10Geysen H M, J, Meloen R H, Barteling S. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid[J]. Proc Natl Acad Sci, USA, 1984, 81: 3998.
化学进展
2004年 第5期

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