黄磷氧化物对大鼠肾脏损害的实验研究

EXPERIMENTAL STUDY ON RENAL INJURY OF THE RATS EXPOSED TO PHOSPHOROUS OXIDE

本实验研究了黄磷急性和亚急性呼吸道染毒对大鼠肾脏的损伤。结果表明:染毒后动物的血清磷、尿磷、肾磷值、尿蛋白含量、尿γ-谷氨酰转移酶(γ-GT)、尿酸性磷酸酶(ACP)的活性均明显高于对照组,而内生肌酐清除率(Ccr)下降。提示黄磷急性染毒对肾小球滤过和肾小管重吸收功能均有一定影响,而亚急性染毒所致肾损伤主要在肾小管。

Acute and subacute toxicity of phosphorous oxide on renal injury had been studied in rats. Phosphorous oxide was given to the rats through respiratory tract. The results showed that the phosphorous level in serum, urine and kidney, the urine protein level, the activity of urine γ-glutarmy transferase (T-GT) and urine acid phosphatase (ACP) of observed group were significantly higher than that of control group, and the endogenous creatinine clearance rate (Ccr) of observed group was significant lower than the rate of control group. It infered that the glomerulus filtration and tubular absorption of kidney could be affected when the rats were acutely intoxicated by phosphorous oxide, and the renal tubules were affected predominantly when the rats were subacute intoxicated by phosphorous oxide.