摘要
应用放射免疫分析法检测正常人和肝硬化患者24小时尿液心房钠尿肽(Atrial natriureticpeptide,ANP)的含量,结果表明15例正常人平均尿 ANP 排泄量为528.0±73.5ng/d;25例肝硬化患者中,伴有腹水者为278.6±83.8ng/d,明显低于正常对照组(P<0.05);而不伴腹水者为456.7±58.9ng/d,与正常对照组比较,无明显减少(P>0.05)。以上结果提示,排泄减少可能与肝硬化患者肝、肾功能减很有关。
The present study was undertaken to assess the clinical significance of urine atrial natriuretic peptide(ANP)in patients with hepatic cirrhosis.A highly sensitive radioimmunoassay(RIA)for determining ANP in 24-hour urine has been established.The average ANP excretion in 15 healthy subjects was 528.0±73.5ng/d and in 11 patients with decompensitive hepatic cirrhosis 278.6±83.8ng/d,which was significantly lower than that of the healthy subjects(P<0.05).It was no significant difference between the eompensitive and normal subjeccts(P>0.05).These results suggest that the reduction of ANP excretion might be due to liver and renal dysfunction in patients with cirrhosis.
关键词
心房钠尿肽
肝硬化
尿
测定
atrial natriuretic peptide
hepatic cirrhosis
urine
determination
