妊娠妇女血中铁状态标记物的病理生理变化

Pathophysiological Changes of Iron Status Markers in Blood During Pregnant Women

目的 :探讨妊娠妇女血中铁标志物浓度的病理生理变化。方法 :测定了 180例妊娠 2月后、产后 10周内和健康受试者血中血液学指标和铁标志物浓度。结果 :妊娠前 3个月sTfR浓度与健康对照间无明显变化(P =0 0 97) ,4个月后sTfR浓度显著增加 (P =0 0 4 3) ,并从该月起 ,sTfR浓度逐渐增加 ,分娩前sTfR浓度最大 (P =0 .0 0 1)。分娩后sTfR浓度迅速降低 ,6～ 8周内回复到正常对照水平 (P =0 10 8)。妊娠 6月后RBC、Hb、Hct、MCV、MCH、MCHC浓度明显低于健康对照 ;分娩 4周后回复到正常对照水平 (P =0 0 5 9)。其余各标志物浓度在妊期内及分娩后无明显差异。结论 :该结果提示sTfR是诊断妊娠妇女铁缺乏的灵敏标志物。妊娠后期血液学指标将降低。

Objective: To investigate the pathophysiological changes of iron status markers in blood during pregnant women.Methods: We measured the hematologic index and the concentrations of iron status marders in 180 pregnant,postpartum,and health women.Results:The sTfR concentrations of pregnant women in the first three month were no significantly difference than that of health women(P=0.097).However,it is significantly increased after 4 months in pregnancy(P=0.043), then gradually elevating ,it is best highest befor delivery(P=0.001),and return to health women values within 6～8 weeks after delivery (P=0.108).As compared to health women, the levels of RBC,Hb, Hct,MCV,MCH,and MCHC were significantly decreased in pregnancy,but return to health women values within 6～8 weeks after delivery(P=0.059).Other markers were no significantly difference in this period. Conclusions:This results suggest that sTfR is a more sensitive indicator of iron deficiency in pregnancy.Hematologic index is decreasing in later stage of pregnancy.