基质金属蛋白酶-9和表皮生长因子受体在非小细胞肺癌中的表达及相关性研究

Study on expression and relationship between MMP-9 and EGFR in NSCLC

目的 :探讨基质金属蛋白酶 9(MMP 9)和表皮生长因子受体 (EGFR)在非小细胞肺癌 (NSCLC)中的表达关系和预后意义。 方法 :采用免疫组化 (S P)法检测MMP 9和EGFR在 6 2例NSCLC组织和 18例正常肺组织中的表达。 结果 :6 2例NSCLC中MMP 9和EGFR阳性表达率分别为 6 7.7%和 5 8.1% ,显著高于 18例癌旁正常肺组织 (P <0 .0 0 5 )。MMP 9和EGFR的表达与肿瘤TNM分期、分化程度及淋巴结转移有关 (P <0 .0 5 )。MMP 9和EGFR的表达呈正相关 (χ2 =6 .4 5 ,P <0 .0 5 )。MMP 9和EGFR与患者的预后密切相关 (P <0 .0 5 )。 结论 :MMP 9。

Objective:To evaluate the relationship and prognostic significance of matrix metalloproteinase-9(MMP-9)、epidermal growth factor receptor(EGFR) in patients with non- small cell lung cancer(NSCLC). Methods:Immunohistochemical method (S-P) was used to detect the expression of the MMP-9、EGFR in 62 NSCLC tissues and 18 normal lung tissues. Results:The positive expression rates of MMP-9 and EGFR were 67.7%,58.1% respectively in the 62 NSCLC.Their expression levels were significantly higher than those in 18 para-cancerous normal lung tissues(P< 0.005).The positive rate of MMP-9、EGFR in lung cancer were closely related to the TNM stages, pathological grades and lymph node involvement(P<0.05).There was the correlation between the MMP-9 and EGFR(χ 2=6.45,P< 0.05).The levels of MMP-9 and EGFR expression were associated with unfavovable prognosis. Conclusion:MMP-9,EGFR could be used as markers of malignant potential and prognosis factor of NSCLC.