期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质金属蛋白酶-9与体外循环肺损伤

Current progress of matrix metalloproteinase in acute lung injury following cardiopulmonary bypass
下载PDF
导出
摘要 肺泡毛细血管基膜损伤是体外循环 (CPB)术后肺损伤发生发展的主要病理过程 ,基质金属蛋白酶 9(MMP 9)可能通过降解细胞外基质、调节细胞因子而参与CPB所致损伤的发生 ,研究MMP 9在CPB肺损伤中的作用机制 。 Degradation of basement membrane of pulmonary capillaries was the main pathological feature of lung injury following cardiopulmonary bypass (CPB). Matrix metalloproteinases-9 (MMP-9) contributed to the development of lung injury following CPB via degredating extracellular matrix and regulating cytokines. So, understanding the effects of MMP-9in the lung injury following CPB may be helpful to prevent and treat the complication mentioned above.
作者 申翼 张宝仁 景华
机构地区 南京军区南京总医院第二军医大学南京临床学院心胸外科
出处 《医学研究生学报》 CAS 2004年第10期925-928,共4页 Journal of Medical Postgraduates
关键词 基质金属蛋白酶-9 体外循环 肺损伤 Matrix metalloproteinase Cardiopulmonary bypass Lung injury
分类号 R654.1 [医药卫生—外科学]
  • 相关文献

参考文献22

  • 1吴二喜,王凤飞,NormanMcKIE.基质金属蛋白酶(英文)[J].生命科学研究,1999,3(3):175-194. 被引量：25
  • 2[2]Asimakopoulos G, Smith PL, Ratnatunga CP et al. Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass[J]. Ann Thorac Surg,1999, 68(3):1107-1115.
  • 3[3]Picone AL,Lutz CJ,Finck C et al. Multiple sequential insults cause post-pump syndrome[J]. Ann Thorac Surg, 1999, 67(4): 978-985.
  • 4[4]Edmunds LH Jr. Inflammatory response to Cardiopulmonary Bypass[J]. Ann Thorac Surg ,1998,66(Suppl 5):S12-16.
  • 5[5]Johnson JL, Moore EE, Tamura DY et al. Interleukin-6 augments neutrophil cytotoxic potential via selective enhancement of elastase release[J]. J Surg Res,1998, 76(1):91-94.
  • 6[6]Carden D, Xiao F, Moak C et al. Neutrophil elastase promotes lung microvascular injury and proteolysisof endothelial cadherins[J]. Am J Physiol, 1998,275(2 pt2):H385-H392.
  • 7[7]McCann UG,Gatto LA, Searles B et al. Matrix metalloproteinase inhibitor: differential effects on pulmonary neutrophil and monocyte sequestration following cardiopulmonary bypass[J]. J Extra Corpor Technol ,1999, 31(2),67-75.
  • 8[8]Carney DE, Lutz CJ, Picone AL et al. Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass[J]. Circulation, 1999 ,100(27):400-406.
  • 9[9]Joffs C, Gunasinghe HR, Multani MM et al.Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases[J]. Ann Thorac Surg ,2001,71(5):1518-1523.
  • 10[10]Mayers I, Hurst T. Cardiac surgery increases the activity of matrix metalloproteinase and nitric oxide synthase in human hearts[J]. J Thoracic Cardiovasc Surg ,2001,122(4):746-752.

二级参考文献14

  • 1Carden D, Xiao F, Moak C et al. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins[J]. Am J Physiol, 1998,275:H385- H392.
  • 2Alexander JS, Elrod JW. Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation[J]. J Anat, 2002,200:561-574.
  • 3Steinberg J, Fink G, Picone A et al. Evidence of increased matrix metalloproteinase-9 concentration in patients following cardiopulmonary bypass[J]. J Extra Corpor Technol, 2001,33:218-222.
  • 4Joffs C, Gunasinghe HR, Multani MM et al. Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases[J]. Ann Thorac Surg,2001,71:1518-1523.
  • 5Yamazaki T, Ooshima H, Usui A et al. Protective effects of ONO5046 Na, a specific neutrohpil elastase inhibitor on postperfusion lung injury[J]. Ann Thorac Surg,1999,68:2141-2146.
  • 6Asimakopoulos G, Smith P, ratnaturga S et al. Lung injury and ARDS after cardiopulmonary bypass[J]. Ann Thorac Surg,1999,68:1107-1115.
  • 7Milot J, Perron J, Lacasse Y et al. Incidence and predictors of ARDS after cardiac surgery[J]. Chest, 2001,119:884-888.
  • 8Teletha SG, Nicolas MB, Thomas PS. Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury[J]. J Immunol,1999, 162: 3653-3662.
  • 9Sternlicht MD,Werb Z. How matrix metalloproteinases regulate cell behavior[J]. Annn Rev Cell Dev Biol,2001,17:463-516.
  • 10Cox CS Jr, Allen SJ, Brennan M. Analysis of intestinal microvascular permeability associated with cardiopulmonary bypass[J]. J Surg Res,1999,83:19-26.

共引文献43

医学研究生学报
2004年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部