表皮钙黏素和nm23蛋白在声门上喉癌中的表达及意义

Expression and significance of E-cadherin and nm23 protein in supraglottic carcinoma

目的 :观察表皮钙黏素和nm2 3蛋白在声门上喉癌组织中的表达 ,探讨其与喉癌临床病理指标间的关系。方法 :应用免疫组化方法观察了 5 7例声门上喉癌组织中表皮钙黏素和nm2 3蛋白的表达。结果 :表皮钙黏素和nm2 3蛋白的表达与喉癌病理分级 (P <0 .0 1)、临床分期 (P <0 .0 1)密切相关。临床检查发现并经病理证实有淋巴结转移 (cN+ pN+ )及临床检查未发现但经病理证实有淋巴结转移 (cN-pN+ )组的表皮钙黏素和nm2 3蛋白的表达均显著高于经病理证实无淋巴结转移组 (pN-) (P <0 .0 1,P <0 .0 5 ) ,而cN+ pN+ 和cN-pN+ 比较无显著差异。结论 :表皮钙黏素和nm2

Objective:To investigate the expression and significance of E-cadherin and nm23 protein in supraglottic carcinoma. [WT5HZ]Methods: E-cadherin and nm23 protein were determined immunohistochemically in 57 cases of supraglottic squamous cell carcinomas, and the relationship between the expression, lymphnode metastasis, cell differentiation and clinical stages were studied. [WT5HZ] Results:The expression of E-cadherin and nm23 protein was significantly lower in pooly differentiated carcinomas than well differentiated ones. Either the losses of E-cadherin or the reductions of nm23 expression was correlated significantly with higher stage. In cN +pN +cases, the expression of E-cadherin and nm23 protein was lower than those in pN - group, the difference was significant. Moreover, the significant reductions of E-cadherin and nm23 protein were observed in carcinomas with occult metastases (cN -pN +), no difference was found between cN +pN +and cN -pN +groups.There was a strong positive correlation between aggressive clinical stage and the lower expression of E-cadherin and nm23 protein.[WT5HZ]Conclusion:E-cadherin and nm23 protein could be useful in prognosis and identifying patients with clinical negative lymphnodes who are at considerable risk for occult metastases. [WT5HZ]