口腔癌快速复发的临床危险因素探讨与分析

Detection and analysis of clinical risk factors for short-term recurrence of oral squamous cell carcinoma

目的 :探讨口腔癌术后快速复发的临床危险因素。方法 :采用病例对照研究 ,将同期口腔鳞癌患者分成快速复发与未复发两组 ,回顾性分析了口腔癌患者的性别、年龄、肿瘤生物学临床特点、手术方式及术后淋巴结转移情况与快速复发的关系 ,统计学采用卡方检验。结果 :两组在发病部位 ,癌肿生长方式 ,TNM分期及病理类型上无明显差异 (P >0 .0 5 ) ,但手术方式和远处淋巴结转移上有显著性差异 (P <0 .0 5 ) ,两组间性别、年龄构成存在显著性差异 ,并且快速复发组女性构成显著增高(P <0 .0 5 )。结论 :年轻患者 (40岁左右 ) ,手术方式和颈淋巴结是否转移是口腔癌术后快速复发的临床危险因素 ,应该强调首次手术治疗的正确性和彻底性 。

Objective:To detect and analyze the clinical risk factors about short-term recurrence of oral squamous cell carcinoma.Methods:A retrospectively comparative research on a total 106 patients with oral squamous cell carcinoma who were divided into two groups according to short-term recurrence and no short-term recurrence,was carried out.All patients had been followed up for one year.The main parameters such as sex,age,tumor region,clinical and pathologic character,TNM stage,surgical management,lymph node metastasis were analyzed statistically,and the results were analyzed by x 2 analysis.Results:①The short-term recurrence rate of oral squamous cell carcinoma was 18.87%.②Age (below 40 year-old),surgical management and neck lymph node metastasis were clinical risk factors related to short-term recurrence of oral squamous cell carcinoma except tumor region,clinical and pathologic character and TNM stage.There was significant difference between two groups( P <0.05).Conclusion:The short-term recurrence rate of oral squamous cell carcinoma is high,and is closely related to age,surgical management and neck lymph node metastasis.Surgical management including continuously radical neck dissection should be applied to this kind of patients,especially younger ones who suffer from oral squamous cell carcinoma.Moreover,the follow-up is of great importance.