溴氧化法合成羟基新戊酸反应条件的研究

Synthesis of Hydroxypivalic Acid by Oxidation of Hydroxypivalaldehyde with Bromine

以羟基新戊醛为原料,以溴为氧化剂制取羟基新戊酸。研究了反应温度、pH、反应物摩尔比、反应物浓度及反应时间与产率、转化率及选择性的关系,并对产品进行了表征。结果表明,溴氧化法合成羟基新戊酸的最佳工艺条件是溴与羟基新戊醛的浓度相等且大于0 1mol/L,pH=0～2,反应温度50℃,反应时间大约2h;最高色谱产率91 0%,分离后化学收率82 4%,选择性可达95%以上。

The optimal reaction conditions for preparation of hydroxypivalic acid from hydroxypivalaldehyde by oxidation with bromine were determined as bromine and hydroxypivalaldehyde in equal molar concentration >0.1 mol/L,pH=0～2,reaction temperature 50 ℃ and reaction time about 2 h.The highest chromatographic yield was 91.0%,the chemical yield was 82.4%,and the selectivity was >95%.